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Alfred G. Knudson, Jr., MD, PhD (photo), a pioneering cancer researcher who is internationally recognized for his groundbreaking “two-hit” hypothesis, which helped provide the basis for our current understanding of the genetic origins of cancer passed away on July 10, 2016 at 93 years of age.
“The [...] cancer research world as a whole has lost a true visionary with the passing of Knudson. He proposed the two-hit hypothesis many years before the molecular technologies needed…Continue
While immune therapy has proven effective in treating certain types of cancer, especially lung cancer and melanoma, tumors of the pancreas remain among the most difficult to treat and, so far, are impervious to immune-based therapies.
Now, for the first time, a new study in mice has shown that immunotherapy against pancreatic cancer can be effective when given in conjunction with drugs that break up the fibrous tissue in these tumors.
The study, from Washington University…Continue
A novel anti-interleukin 1-alpha antibody has shown a significant impact on symptoms, and a high level of safety and tolerability in patients with advanced colorectal cancer, according to phase III data presented at the European Society for Medical Oncology’s 18th World Congress of Gastrointestinal Cancer in Barcelona, Spain. 
Xilonix™ (XBiotech) is the first…Continue
Improved cancer detection and treatment efforts, combined with demographic trends, are creating larger numbers of older cancer survivors who are likely to have other health conditions that impact care and well-being. This is the conclusion of new research published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American…Continue
This week Targovax, a clinical stage immuno-oncology company developing targeted immunotherapy treatments for cancer patients, announced that the first patient has been dosed in a phase Ib/II clinical trial evaluating ONCOS-102 for the treatment of malignant pleural mesothelioma (MPM), a rare type of cancer in the lining of the lung, in combination with pemetrexed and cisplatin.
ONCOS - 102 is a virus-based immunotherapy platform based on engineered…Continue
Dosing of the first patient in a Phase I clinical trial of BGB-3111, a Bruton’s tyrosine kinase (BTK) inhibitor, in combination with BGB-A317, a PD-1 antibody, for the treatment of various B-cell malignancies was initiated earlier this week. This combination study of two internal drug candidates being developed by BeiGene, a clinical-stage biopharmaceutical company focused on developing molecularly targeted and immuno-oncology drugs for the treatment of cancer, follows an ongoing study of…Continue
Women with a history of severe cervical intraepithelial neoplasia, a precancerous condition of the cervix that arises from infection with the human papillomavirus (HPV), had a long-term increased risk of developing anal, vulvar, and vaginal cancer. This is the conclusion of a study, funded by the Unit of Virus, Lifestyle, and Genes at the Danish Cancer Society Research Center, published in Cancer Epidemiology,…Continue
Following cancer prevention guidelines on diet and physical activity consistently reduced overall cancer incidence and mortality, as well as reducing risk of breast, endometrial, and colorectal cancers. Conclusions of the study, funded by a National Cancer Institute Cancer Center support grant, were published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the …Continue