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A study published in the February 24, 2015 issue of JAMA, the Journal of The American Medical Association, suggests that children with acute lymphoblastic leukemia who had a certain gene variant experienced a higher incidence and severity of peripheral neuropathy after receiving treatment with the cancer drug vincristine (Oncovin®/ Vincasar Pfs®).
Despite major advances over the last 2 decades, cancer remains the leading cause of death by disease in children in the United…Continue
ONC201 is a small molecule inducer of the TRAIL gene under current investigation as a novel anticancer agent. The small molecule drug has a unique mechanism of action that causes significant anti-tumor activity in a variety of types of human cancer.
In an article published OnlineFirst on February 13, 2015 in Cancer Research, a journal published by the American Association for Cancer Research (AACR), Professor Wafik El-Deiry, MD, PhD, FACP, Co-Program Leader of Molecular…
A new analysis has found that many women with breast cancer lack knowledge about their illness, with minority patients less likely than white patients to know and report accurate information about their tumors’ characteristics.
Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings highlight the need to educate patients about their…Continue
The U.S. Food and Drug Administration (FDA) has approved panitumumab (Vectibix®, Amgen) for use in combination with FOLFOX, an oxaliplatin-based chemotherapy regimen, as first-line treatment in patients with wild-type KRAS (exon 2) metastatic colorectal cancer (mCRC).
With an estimated number of 96,830 colon and 40,000…Continue
Just a little more than a week before the start of the 50th Annual Meeting of ASCO, the American Society of Clinical Oncology in Chicago, Il, the news landed on my desk that Selma Schimmel, founder and CEO of Vital Options International and an outspoken activist, patient advocate, respected radio talk show host and author had died, aged 59, from malignant psoas syndrome or MPS, a…Continue
One of the first studies to analyze the effectiveness of screening survivors of childhood cancer for early signs of impending Congestive Heart Failure or CHF finds improved health outcomes. Hoever, the study suggests that less frequent screening than currently recommended may yield similar clinical benefit. The researchers, in a study published in the Annals of Internal Medicine, utilized a simulation-based…Continue
The majority of cancers today are detected on the macroscopic level, when the tumor already includes millions of cancer cells and the disease is starting to advance into a more mature phase. But what if we could diagnose cancer before it took hold- while it was still only affecting a few localized cells? It could be compared to putting a fire out while there are just a few sparks.
An international team of researchers, led by…Continue
A study published this week as an early online publication in Cancer Epidemiology, Biomarkers & Prevention shows that according to a recent comprehensive analysis of lung cancer rates for women around the world lung cancer rates are dropping in young women in many regions of the globe. The authors of the article suggest that their data points to the success of tobacco control efforts.
However, the data also shows that rates continue to increase among older women in many…Continue
Researchers from University Hospitals (UH) Case Medical Center's Seidman Cancer Center found that the presence of tumor-infiltrating lymphocytes, a type of white blood cell, ahead of treatment, may help predict response to platinum-based chemotherapy in women with triple-negative breast cancer. The data, which comes from the PrECOG 0105 trial, will be presented at the 50th annual meeting of the American Society for Clinical…Continue
A study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research (AACR) showed that young adults who smoked water pipes in hookah bars had elevated levels of nicotine, cotinine, tobacco-related cancer-causing agents, and volatile organic compounds or VOC in their urine, increasing their risk for cancer and other chronic diseases.
Commenting on the study, Gideon…Continue