January 2010 Blog Posts (6)

Cancer Tutorial: What is Cancer?

Cancer is not a single disease but rather a group of diseases characterized by the proliferation of cells that bypass regulatory checkpoints of the cell-cycle and/or escape induction of apoptosis (reviewed in Bocchetta and Carbone, 2004). In general, the proteins responsible for maintaining DNA and the cell cycle can be divided into six categories that include: (1) cytokines/growth factors (2) growth factor receptors; (3) intracellular signaling molecules; (4) transcription factors; (5)… Continue

Added by Roxanne Engel, PhD on January 29, 2010 at 5:36pm — No Comments

First Targeted Biological Therapy to Show Survival Benefit in Stomach Cancer

The European Commission has approved trastuzumab (herceptin, Roche Pharmaceuticals) in combination with chemotherapy for use in patients with HER2-positive metastatic stomach (gastric) cancer.

Trastuzumab is a humanized antibody, designed to target and block the function of HER2, a protein produced by a specific gene with cancer-causing potential. The mode of action of trastuzumab is unique in that it activates the body’s immune system and suppresses HER2 to target and… Continue

Added by Peter Hofland, PhD on January 29, 2010 at 5:00am — No Comments

National Discussion on Proper Use and Support of Oral Chemotherapy in Cancer Care

The growing use of oral chemotherapeutics brings clinical benefits but also raises questions in prescribing, adherence, accessibility and long term follow-up care. Therfore, US Oncology, Inc. partnered with the Association of Community Cancer Centers, Association of Oncology Social Work, American Society for Clinical Oncology, Community Oncology Alliance, Oncology Nursing Society and the National Patient Advocate Foundation in… Continue

Added by Peter Hofland, PhD on January 22, 2010 at 5:00pm — No Comments

Studies Show Benefit of Advance Detection and Treatment of Gastrointestinal Cancers

A great number of the world's preeminent gastroenterologists will gather during the seventh annual Gastrointestinal Cancers Symposium (ASCO GI) from January 22-24, 2010, at the Orlando World Center Marriott to discuss new research on the treatment of gastrointestinal cancers.

Presentations at the meeting will focus on detection and treatment of gastrointestinal cancers, which includes cancers of the colon/rectum, stomach, pancreas, esophagus, small intestine, anus and… Continue

Added by Peter Hofland, PhD on January 22, 2010 at 5:00pm — No Comments

MRI Screening Refused by Many Women at Risk for Breast Cancer - AMAS Test can be an alternative

Original post from Paul Navitsky at Oncolab (www.oncolabinc.com)

CancerConsultants.com (an informational cancer website) posted an article citing an American College of Radiology Imaging Network study that found approximately 58% of women with a high risk of breast cancer agreed to a MRI screen while the remainder refused for a variety of reasons.

Many of… Continue

Added by Pat Gouttebel on January 7, 2010 at 5:58pm — No Comments

Cancer Tutorial: Introduction to Drug Resistance

Although the development of new drugs and new drug combinations has resulted in more effective treatment of cancer, a major factor limiting their usefulness is the presence of drug-resistant cancer cells that can exist prior to (intrinsic or de novo drug resistnace) or arise during cancer therapy (acquired drug resistance). Whether drug resistance is intrinsic or acquired, mechanisms conferring altered drug sensitivity may be categorized as invloving a pre-target event, a drug-target… Continue

Added by Roxanne Engel, PhD on January 6, 2010 at 11:41am — No Comments

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