January 2013 Blog Posts (22)

Study Evaluating Recombinant Fusion Protein Linking Coagulation Factor IX with Albumin (rIX-FP) in Patients with Severe Hemophilia B Starts Enrolling Patients

Earlier today the first patient has been enrolled in the pivotal pediatric phase III study to evaluate the safety, efficacy and pharmacokinetics of recombinant fusion protein linking coagulation factor IX with recombinant albumin (rIX-FP) in previously treated children (up to age 11 years). The study site for this first enrollment is the Czech Republic.

Hemophilia is an inherited bleeding disorder characterized by prolonged or spontaneous bleeding, especially into the muscles…

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Added by Peter Hofland, PhD on January 31, 2013 at 8:30pm — No Comments

Phase III Trial of Obinutuzumab (GA101) Shows Significantly Improvement of Progression-Free Survival in People With Chronic Lymphocytic Leukemia (CLL)

Positive results from the stage I part of CLL11, a Phase III randomized study shows an improvement in progression-free survival (PFS) and significantly reduced the risk of Chronic Lymphocytic Leukemia (CLL) worsening or death compared to chlorambucil alone.

Hematological malignancies are cancers of the blood and include CLL, indolent NHL and diffuse large B-cell lymphoma (DLBCL). In 2013, it is expected that there will be nearly 19,020 annual deaths from NHL and nearly 4,580…

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Added by Peter Hofland, PhD on January 30, 2013 at 7:30pm — No Comments

High Unmet Need for Better-Tolerated Treatments Directed Toward Elderly Patients Drives Growth in Leukemia Market

Novel targeted therapies hold the most promise for improving outcomes for patients with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). This is the conclusion published in two reports by Decision Resources. Key Opinion Leaders (KOL) and medical experts interviewed for these reports are enthusiastic about the potential of blinatumomab (Amgen/MicroMet),…

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Added by Peter Hofland, PhD on January 30, 2013 at 8:30am — No Comments

New Campaign Designed to Ensure that Young Girls are Protected Against Cervical Cancer

In the United Kingdom, almost 3,400 women are diagnosed with cervical cancer each year, representing nearly 2% of all women diagnosed with cancer. Cervical cancer is, however, the most common cancer in women under 35 years old.

The major cause of the main types of cervical cancer - squamous cell cancer and adenocarcinoma - is HPV infection. [5] While there are over 200 types of human papilloma virus (HPV)[8], at least 40 types are passed on through sexual contact and cause a…

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Added by Peter Hofland, PhD on January 30, 2013 at 12:30am — No Comments

Prostate Cancer Deaths Estimated to Grow While Diagnosed New Cases are Expected to Decrease

A new report published today estimates a 5% increase in prostate cancer deaths in 2013 and signal a new trend of fewer men being diagnosed with the disease. Compared to a 15% decrease in prostate cancer deaths in 2012, this year's increase could be attributed to men with aggressive forms of the disease forgoing early detection.

"We must remain vigilant in the fight to end prostate cancer by increasing research funding, raising awareness and education, and continuing to test…

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Added by Peter Hofland, PhD on January 29, 2013 at 7:30pm — No Comments

Common Genetic Pathway Activation may not be “Driving” Effective Treatment in Head and Neck Cancers

A large majority of head and neck cancers have a deregulation of the PI3K/AKT/mTOR pathway. However, data published recently in Cancer Research, a journal of the American Association for Cancer Research (AACR), suggests that deregulation of this pathway does not necessarily signify that the tumor is dependent on it for survival and progression. While the common pathway activation may not be “driving” tumor,…

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Added by Peter Hofland, PhD on January 29, 2013 at 7:00pm — No Comments

Deregulation of Several Genetic Pathways may Explain Treatment Resistance in Head and Neck Cancers

Although a large majority of head and neck cancers have a deregulation of the PI3K/AKT/mTOR pathway, data recently published in Cancer Research, a journal of the American Association for Cancer Research, indicated that deregulation of this pathway does not necessarily signify that the tumor is dependent on it for survival and…

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Added by Peter Hofland, PhD on January 29, 2013 at 11:30am — No Comments

Multinational Harmonization and Collaboration Needed - Regulators and Hospital Urged to Avoid Unnecessary Delays in Approving Important Clinical Trials

A study published in The Oncologist emphasizes the critical need for regulatory authorities, pharmaceutical clinical study sponsors, collaborative research groups and other interests to work together to expedite study approval for clinical trials in cancer research on a global scale. The study highlighting the need to avoid unnecessary delays in approving clinical trials.[1]

In their research paper Otto…

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Added by Peter Hofland, PhD on January 28, 2013 at 4:30pm — No Comments

New Phase II Trial in Advanced/Metastatic Soft Tissue Sarcoma Initiated

Soft tissue sarcomas (STS), diverse, malignant, mesenchymal tumors that originate in the soft tissues of the body, while uncommon, generally affect young adults in the prime of their life. The tumors arise in any of the mesodermal tissues of the extremities (50%), trunk and retroperitoneum (40%), or head and neck (10%). The prognosis for patients with advanced/metastatic sarcoma remains poor and there are limited options for their treatment. In the US, the number new cases of soft tissue…

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Added by Peter Hofland, PhD on January 26, 2013 at 11:30am — No Comments

New Evidence Demonstrates Clinical Utility and Cost-Effectiveness of Colon Cancer Test

Results from three studies of the Oncotype DX® Colon Cancer test (Genomic Health) presented the 2013 ASCO Gastrointestinal Cancers Symposium, show that diagnostic test significantly contribute to changes in treatment decisions.

The various studies confirm that the Recurrence Score® (RS) results changed treatment recommendations in 45% of the enrolled stage II…

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Added by Editorial Team on January 24, 2013 at 1:30pm — No Comments

Changes in Volume of Telomeric DNA may Help Increase Undertanding of Particular Cancers and their Underlying Genetic Mistakes

Researchers are taking a new approach to measuring the repetitive DNA at the end of chromosomes. Understanding the nature of this repetitive DNA may help open new windows to understanding mechanisms fueling cancer.

Genome sequencing data once regarded as junk is now being used to gain important clues to help understand disease. The latest example comes from the St. Jude Children's Research Hospital – Washington University…

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Added by Peter Hofland, PhD on January 24, 2013 at 12:30pm — No Comments

Study Shows Smokers Lose a Decade of Life Expectancy Compared to Non-smokers

Two new studies published today in the New England Journal of Medicine find huge health benefits of smoking cessation. "Smoking remains a huge public health problem in the United States, but smokers who quit between the ages of 25 and 34 regained nearly the same life expectancy as people who had never smoked. The message to smokers is clear: The sooner you quit, the greater the health benefits," noted Matthew L. Myers, President, …

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Added by Peter Hofland, PhD on January 23, 2013 at 6:00pm — No Comments

Targeting P13K May Delay Anti-HER2 Therapy Resistance in Breast Cancer Patients

The phosphatidylinositol-3 kinase or PI3K signaling pathway has been identified as a valid target in a large number of cancers. It is probably one of the most important pathways in cancer metabolism and growth. Mutations in the PI3K pathway are frequent in breast cancer, ovarian and endometrial cancers, causing resistance to human epidermal growth factor receptor 2–targeted agents and, possibly, to hormonal agents as well. Available agents that affect the PI3K pathway include monoclonal…

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Added by Peter Hofland, PhD on January 23, 2013 at 1:30pm — No Comments

Discovery of Promising Prognostic Marker for Aggressive Breast Cancer may Lead to New Therapies

A team of researchers led by Goutham Narla, MD, PhD, at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, and collaborators at the Mount Sinai School of Medicine and Erasmus Medical Center, have discovered a gene variant that drives the spread of breast cancer.

The results of the study are published in…

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Added by Peter Hofland, PhD on January 23, 2013 at 11:30am — No Comments

Test Predicts Presence of BRCA1 and BRCA2 Mutations with High Sensitivity and Specificity, Aiding Clinical Decision Making

About 5% of all breast cancers are attributed to an inherited mutation in one of two cancer susceptibility genes, BRCA1 and BRCA2. Researchers how now developed a new multiple gene expression profile test was able to predict the presence of either BRCA1 or BRCA2 mutations in otherwise healthy women carrying the mutations, according to data published in Cancer Prevention Research, a…

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Added by Peter Hofland, PhD on January 22, 2013 at 6:00pm — No Comments

Study Confirms Improved Survival in Advanced Pancreatic Cancer with Nanoparticle Albumin-bound Paclitaxel plus Gemcitabine

A new phase III study confirms that the breast cancer drug nanoparticle albumin-bound paclitaxel (Abraxane®, Celgene) in combination with gemcitabine (Gemzar®, Eli Lilly and Company), the current standard of for advanced pancreatic cancer, demonstrated highly statistically significant and clinically meaningful results across primary and key secondary endpoints and patient…

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Added by Peter Hofland, PhD on January 22, 2013 at 4:30pm — No Comments

New, First of its Kind, Childhood Cancer Prevention and Screening Clinic Screens Children who are most Susceptible to Childhood Cancers

Earlier today, the Texas Children's Cancer Center announced a new, first of its kind, Childhood Cancer Prevention and Screening Clinic which will screen and follow children who are at an elevated risk for developing childhood cancer.

The new clinic will reassure families of children with genetic conditions such as Li-Fraumeni syndrome and Beckwith-Wiedemann syndrome which predispose individuals to…

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Added by Editorial Team on January 21, 2013 at 9:30am — No Comments

Understanding of Genetic Basis of Childhood Cancer may Lead to New Treatment Strategy

A study published in the January 20 advance online edition of the scientific journal Nature Geneticsfinds new genetic defects in high-risk childhood leukemia subtypes with chromosomal loss.[1] This research confirms evidence that some patients have an inherited cancer syndrome

The researchers, led by St. Jude Children’s Research Hospital scientists, identified a possible lead in…

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Added by Peter Hofland, PhD on January 20, 2013 at 5:00pm — No Comments

Understanding of Genetic Basis of Childhood Cancer may Lead to New Treatment Strategy

A study published in the January 20 advance online edition of the scientific journal Nature Geneticsfinds new genetic defects in high-risk childhood leukemia subtypes with chromosomal loss.[1] This research confirms evidence that some patients have an inherited cancer syndrome

The researchers, led by St. Jude Children’s Research Hospital scientists, identified a possible lead in…

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Added by Peter Hofland, PhD on January 20, 2013 at 5:00pm — No Comments

Multicenter Gene Sequencing Study of Neuroblastoma Shows Fewer Obvious Treatment Targets

Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. While most neuroblastomas strike in a young child's chest or abdomen in the adrenal gland or next to the spinal cord, or in the chest, the disease can spread to the bones (face, skull, pelvis, shoulders, arms, and legs), bone marrow, liver, lymph nodes, skin, and around the eyes (orbits). Neuroblastoma is most…

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Added by Editorial Team on January 20, 2013 at 11:00am — No Comments

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