February 2010 Blog Posts (2)

Cancer Tutorial: DNA Topoisomerases as Targets of Anti-cancer Agents

The human genome consists of approximately 3.2 billion base pairs and would be about 2 meters in length, if stretched out from end to end (Porter et al., 2004). Nevertheless, DNA squeezes into the nucleus of a cell, which is approximately 6uM in diameter. For example, the smallest human chromosome is 14 mm long but is compacted to just 2 uM in length (Ball, 2003). Thus, DNA exists in a tightly compacted and dense form. Conversely, DNA must also allow itself to become accessible to numerous… Continue

Added by Roxanne Engel, PhD on February 3, 2010 at 7:21pm — No Comments

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