April 2013 Blog Posts (25)

ASCO President Discusses the Theme for 2013's Annual Meeting: "Building Bridges to Conquer Cancer."

This year, the Annual Meeting of the American Society of Clinical Oncology (ASCO) will be held in Chicago from may 31 - June 4, 2013.  ASCO president Sandra M. Swain, MD, FACP discusses the importance of her presidential theme, "Building Bridges to Conquer Cancer." This theme serves to emphasize the…

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Added by Editorial Team on April 30, 2013 at 11:30pm — No Comments

Radioactive Listeria Bacteria Shows Promise As a Target Against Metastatic Pancreatic Cancer

The treatment of patients with pancreatic cancer has not seen significant improvement over the last 25 years. The current state underscores the urgent need for new and alternative therapies.

Researchers at Albert Einstein College of Medicine of Yeshiva University trying to meet these needs have developed a new therapy for pancreatic cancer that uses Listeria bacteria to selectively infect tumor cells and deliver…

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Added by Editorial Team on April 24, 2013 at 3:30pm — No Comments

Precancerous Lesions are More Common in Benign Biopsy Specimens from Obese Men - Increasing Risk for Prostate Cancer

Obesity has been associated with risk of high-grade prostate cancer in the general population. However, until now, very little is known about obesity and the risk or development of future prostate cancer risk among men with an initial benign biopsy of the prostate. Now, according to a new study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the…

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Added by Editorial Team on April 23, 2013 at 6:30pm — No Comments

Cancer Care Community Praises Group of Bipartisan Lawmakers for Urging Centers for Medicare and Medicaid Services to Review Results of Sequester Cuts

The United States Congress has come to the aid of Medicare patients and their providers to stop the harmful sequester cut important cancer drugs. Earlier today, a community of American cancer care organizations, including the American Society of Clinical Oncology (ASCO), Community Oncology Alliance (COA),…

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Added by Editorial Team on April 23, 2013 at 1:00pm — No Comments

Water-pipe Smoking Exposes Smokers to a Different Risk Profile than Cigarette Smoking: Water-pipe is Not a Safer Alternative

Smoking the 'hookah' or water-pipe has gained popularity outside of its native region in India, Pakistan and the Middle East, and is gaining popularity in North America and Europe. Most 'hookah-smokers' perceive water-pipe smoking to be considerable less hazardous than cigarette smoking because they believe that a water-pipe filters out the toxic components of tobacco. However, results from a study published in…

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Added by Editorial Team on April 19, 2013 at 10:00pm — No Comments

Arguments Challenging Patents on Breast and Ovarian Cancer Gene Heard by U.S. Supreme Court

The U.S. Supreme Court heard arguments Monday in a case seeking to invalidate patents on two genes associated with hereditary breast and ovarian cancer. The American College of Medical Genetics and Genomics (ACMG) was one of the first plaintiffs to sign onto this historic legal case.

The American College of Medical Genetics and Genomics was also the first professional medical association to establish a position…

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Added by Editorial Team on April 17, 2013 at 2:30pm — No Comments

A Statewide Comprehensive Cancer Control Screening Program Shows Better Outcomes for Minority Patients in Delaware - No Increase of Overall Health System Costs

Colorectal cancer (CRC) is the third most common cancer diagnosed in man and women in the United States. According to estimates from the American Cancer Society, 102,480 new patients will be diagnosed with CRC in 2013. A further 40,340 patients will be diagnosed with rectal cancer. CRC is expected to cause about 50,830 deaths in the United States during 2013.

The same estimates show that the overall, the lifetime risk of developing colorectal cancer is about 1 in 20 (5.1%).…

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Added by Editorial Team on April 15, 2013 at 3:00pm — No Comments

Calcium Intake Associated With Reduced Colorectal Adenoma Risk; Variations in Two Genes may be Responsible

Researchers at the Vanderbilt-Ingram Cancer Center and Vanderbilt University School of Medicine in Nashville, Tennessee, have identified a potential explanation for inconsistent results from prior studies about the association between calcium intake and risk for colorectal adenomas, which are precursors to colorectal cancers.

The findings were presented at the Annual Meeting of the…

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Added by Editorial Team on April 10, 2013 at 3:00pm — No Comments

Increased Physical Activity Related to Lower Urinary Levels of Estrogens and Estrogen Metabolites in Postmenopausal Women

Data presented at the 2013 annual meeting of the American Association for Cancer Research (AACR) held in Washington, D.C., April 6-10, 2013, shows the effect of increased physical activity on estrogen levels in postmenopausal women. The data generated new insights into the ways in which physical activity affects how much estrogen is broken down and secreted in the urine. These findings enhance understanding of the potential biological…

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Added by Editorial Team on April 9, 2013 at 9:30pm — No Comments

Increased Physical Activity Related to Lower Urinary Levels of Estrogens and Estrogen Metabolites in Postmenopausal Women

Data presented at the 2013 annual meeting of the American Association for Cancer Research (AACR) held in Washington, D.C., April 6-10, 2013, shows the effect of increased physical activity on estrogen levels in postmenopausal women. The data generated new insights into the ways in which physical activity affects how much estrogen is broken down and secreted in the urine. These findings enhance understanding of the potential biological…

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Added by Editorial Team on April 9, 2013 at 9:30pm — No Comments

Investigational RNA Interference Drug Silences the PLK1 Gene Involved in Tumor Growth in Phase I Trial

According to researchers, initial phase I, first in-human, trial results for TKM-080301, also known as TKM-PLK1, indicate that a potential new class of drugs called RNA interference (RNAi) drugs, can be safely administered in humans. The early results for the drug, which is being developed by Tekmira Pharmaceuticals Corporation, were presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10, 2013.

Commenting on the early trial results, Ramesh K.…

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Added by Editorial Team on April 9, 2013 at 5:30pm — No Comments

Mothers Exposure to Air Pollution During Pregnancy Associated with an Increased Incidence of Pediatric Acute Lymphoblastic Leukemia, Retinoblastoma and Germ Cell Tumors

Results of a study presented during the Annual Meeting of the American Association for Cancer Research shows that increased exposure to traffic-related air pollution during pregnancy was associated with a higher incidence of acute lymphoblastic leukemia and two rare childhood cancers.

“The main reason for undertaking this study was that we know much more about the causes of adult cancers than we do of the causes of childhood cancers,” said…

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Added by Editorial Team on April 9, 2013 at 3:30pm — No Comments

Higher Levels of Selenium are Associated with a Reduced Risk of Advanced Prostate Cancer - May Be Protective

Date presented at the Annual Meeting of the American Association for Cancer Research held this year in Washington, D.C., from April 6 to 10, shows that a greater level of toenail selenium was associated with a significant decrease in the risk for advanced prostate cancer.[1]

Selenium, a trace mineral that is essential to good health and exerts important biological functions. As part of a healthy diet, it is required only in small amounts [2] [3]. Selenium is incorporated into…

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Added by Editorial Team on April 9, 2013 at 12:30pm — No Comments

PD-L1 Antibody MPDL3280A is well Tolerated in Phase I Study - No Limiting Toxicities Across a Range of Cancer Types

The programmed death-ligand 1 (PD-L1), the primary ligands of the programmed death 1 (PD-1) protein, a T-cell coinhibitory receptor and immunoinhibitory receptor of the CD28 family, plays a pivotal role in the ability of tumor cells to evade the host's immune system. PD-L1 is selectively expressed on many tumors and on cells…

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Added by Editorial Team on April 9, 2013 at 12:00am — No Comments

More than 2% of Melanoma Survivors Still Use Tanning Beds, 27% Skip Sunscreen

Although most survivors of melanoma take precautions to protect their skin from the sun and further occurrences of cancer, data presented at the Annual Meeting of the American Association for Cancer Research (AACR) held in Washington, D.C., April 6-10, 2013 revealed that more than a quarter (27%) do not use sunscreen when outside for more than an hour. The same data also shows that more than 2% still use tanning beds.

Commenting on the remarkable data,…

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Added by Editorial Team on April 8, 2013 at 10:00pm — No Comments

Study Shows that Adding Cetuximab to Chemotherapy Enables Previously Inoperable Patients with Advanced Colorectal Cancer and Liver Metastasis to Undergo Surgery

Nearly one third of all patients diagnosed with colorectal cancer (CRC) are diagnosed with metastatic disease or Stage IV disease. If surgical resection of the (liver) metastases is not possible in these cases and the lesion or lesions are considered inoperable, there limited liver directed treatment options available.

New results from a phase III clinical trial conducted in Shanghai, China, shows that adding cetuximab (…

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Added by Editorial Team on April 8, 2013 at 9:00pm — No Comments

ARQ 092 - a Novel AKT Pathway Inhibitor - Demonstrated Safe and Effective Target Inhibition

Results from a Phase I trial shows that a novel oral cancer drug, ARQ-092 (ArQule, Inc), inhibits the AKT pathway and has a manageable safety profile in patients with a variety of advanced solid tumors. Researchers confirmed this during the Annual Meeting of the American Association for Cancer Research (AACR), held in Washington, D.C., April 6-10, 2013.…

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Added by Editorial Team on April 8, 2013 at 12:30pm — No Comments

Phase II Monotherapy Study of Ibrutinib Shows CLL Patients Achieved Rapid and Sustainable Disease Control Irrespective of Age or High Risk Prognostic Factor

Results from a Phase II trial shows that ibrutinib (also known as PCI-32765; 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one; Janssen Biotech, Inc. and Pharmacyclics), a first-in-class oral therapy that is a selective, irreversible, inhibitor of Bruton’s tyrosine kinase (BTK), offers rapid and sustained disease control as a monotherapy in untreated, relapsed and refractory chronic lymphocytic leukemia (CLL) patients, irrespective of…

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Added by Peter Hofland, PhD on April 8, 2013 at 11:00am — No Comments

Study Shows Women with BRCA1 Mutations are 1.2 times More Likely to Die from Breast Cancer: ER+ Tumors Less Prevalent Among those with BRCA1 Mutation

Results from a large Dutch study shows that women with breast cancer who had a BRCA1 mutation had significantly worse overall and recurrence-free survival rates compared with patients without BRCA mutations, but no evidence for a difference in survival was found between patients with BRCA2 mutations and those without a BRCA mutation. The data was presented during the Annual Meeting of the American Association for Cancer Research (AACR)…

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Added by Editorial Team on April 8, 2013 at 12:30am — No Comments

Biomarker May Help Predict Response to Drugs Targeting KRAS-mutated NSCLC

Epidermal Growth Factor Receptor (EGFR) and KRAS are the most commonly mutated oncogenes in lung cancer. EGFR kinase domain mutations have been established as valid predictors of increased sensitivity to gefitinib (Iressa, AstraZeneca) and erlotinib (Tarceva, Genentech). On the other hand, patients with mutant KRAS tumors fail to benefit from adjuvant chemotherapy and their disease…

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Added by Editorial Team on April 7, 2013 at 4:30pm — No Comments

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