May 2014 Blog Posts (18)

DMOT4039A Shows Anticancer Activity in Patients with Pancreatic or Ovarian Cancer

A study presented at the 50th Annual Meeting of the American Society for Clinical Oncology (ASCO) being held May 30 - June 3, 2014 in Chicago, Ill, describes the results of a phase I clinical trial of the investigational agent DMOT4039A against pancreatic and ovarian cancers. In this early clinical trial with the goal of identifying possible risks and defining likely dosages, the drug was well tolerated and in some patients showed initial evidence of anti-cancer…

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Added by Editorial Team on May 30, 2014 at 9:30pm — No Comments

Dutch Oncologist Receives Prestigious Karnofsky Memorial Award

Bob Pinedo, MD, PhD, a Professor Emeritus of the VU University Medical Center (VUmc), and a consultant to the Board of the VUmc Cancer Center, Amsterdam, The Netherlands has been awarded by the American Society of Clinical Oncology (ASCO) David A. Karnofsky Memorial Award.

As a clinical investigator taking new concepts into early clinical trials, Pinedo has made seminal observations in cancer biology and treatment-related mechanisms of drug action and resistance in the…

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Added by Editorial Team on May 25, 2014 at 6:30pm — No Comments

First-line Treatment with Panitumumab + FOLFOX in Patients with Wild-type KRAS Metastatic Colorectal Cancer Approved

The U.S. Food and Drug Administration (FDA) has approved panitumumab (Vectibix®, Amgen) for use in combination with FOLFOX, an oxaliplatin-based chemotherapy regimen, as first-line treatment in patients with wild-type KRAS (exon 2) metastatic colorectal cancer (mCRC). 

With an estimated number of 96,830 colon and 40,000…

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Added by Peter Hofland, PhD on May 23, 2014 at 5:30pm — No Comments

Thank you Selma!

Just a little more than a week before the start of the 50th Annual Meeting of ASCO, the American Society of Clinical Oncology in Chicago, Il, the news landed on my desk that Selma Schimmel, founder and CEO of Vital Options International and an outspoken activist, patient advocate, respected radio talk show host and author had died, aged 59, from malignant psoas syndrome or MPS, a…

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Added by Peter Hofland, PhD on May 21, 2014 at 8:00pm — No Comments

Revisiting Cardiac Screening Guidelines for Survivors of Childhood Cancer: Less Frequent Screening may be Beneficial

One of the first studies to analyze the effectiveness of screening survivors of childhood cancer for early signs of impending Congestive Heart Failure or CHF finds improved health outcomes. Hoever, the study suggests that less frequent screening than currently recommended may yield similar clinical benefit. The researchers, in a study published in the Annals of Internal Medicine, utilized a simulation-based…

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Added by Peter Hofland, PhD on May 19, 2014 at 3:00pm — No Comments

Ultra-sensitive Nano-chip Capable of Detecting Early-stage Cancer

The majority of cancers today are detected on the macroscopic level, when the tumor already includes millions of cancer cells and the disease is starting to advance into a more mature phase. But what if we could diagnose cancer before it took hold- while it was still only affecting a few localized cells? It could be compared to putting a fire out while there are just a few sparks.

An international team of researchers, led by…

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Added by Peter Hofland, PhD on May 18, 2014 at 1:00pm — No Comments

The Success of Tobacco Control: Study Shows Global Drop in Lung Cancer Rates in Young Women

A study published this week as an early online publication in Cancer Epidemiology, Biomarkers & Prevention shows that according to a recent comprehensive analysis of lung cancer rates for women around the world lung cancer rates are dropping in young women in many regions of the globe. The authors of the article suggest that their data points to the success of tobacco control efforts.

However, the data also shows that rates continue to increase among older women in many…

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Added by Peter Hofland, PhD on May 16, 2014 at 10:30pm — No Comments

Experts Find New Ways to Predict Response to Chemo in Triple-negative Breast Cancer

Researchers from University Hospitals (UH) Case Medical Center's Seidman Cancer Center found that the presence of tumor-infiltrating lymphocytes, a type of white blood cell, ahead of treatment, may help predict response to platinum-based chemotherapy in women with triple-negative breast cancer. The data, which comes from the PrECOG 0105 trial, will be presented at the 50th annual meeting of the American Society for Clinical…

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Added by Peter Hofland, PhD on May 16, 2014 at 2:00pm — No Comments

Water Pipe-smoking Significantly Increases Exposure to Cancer Causing Agents

A study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research (AACR) showed that young adults who smoked water pipes in hookah bars had elevated levels of nicotine, cotinine, tobacco-related cancer-causing agents, and volatile organic compounds or VOC in their urine, increasing their risk for cancer and other chronic diseases.

Commenting on the study, Gideon…

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Added by Peter Hofland, PhD on May 16, 2014 at 2:00pm — No Comments

Researchers find New MicroRNA that may help in Suppressing Prostate Cancer Progression

Prostate cancer is the second most common cancer and the second leading cause of cancer-related death in men in the United States. Based on recent data, it is estimated that, in 2013, nearly 239,000 men will be diagnosed with prostate cancer, and nearly 30,000 men will die of the disease. Furthermore, it is estimated that approximately $11.9 billion is spent each year in the United States on prostate cancer treatment.

This is why findings by…

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Added by Peter Hofland, PhD on May 16, 2014 at 12:00pm — No Comments

Government Report Shows that Hospital Care is Improving

In a new report published this month,  the Agency for Healthcare Research and Quality (AHRQ), a research agency within the U.S. Department of Health and Human Services (HHS), presents data showing that hospitals are leading the movement to improve the quality of care delivered to U.S. patients, outpacing improvements in other settings. According to the report, three-quarters of hospital quality measures showed significant improvement, compared with 60% for home health and nursing home…

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Added by Editorial Team on May 15, 2014 at 8:30pm — No Comments

Researchers to Present Important New Data for ibrutinib in B-Cell Malignancies

During the upcoming annual meeting of the American Society of Clinical Oncology (ASCO), to be held May 30 - June 3, 2014, in Chicago, Il, results from the Phase III Resonate™ trial with Ibrutinib (PCI-32765, Imbruvica®; Pharmacyclics), will be featured in ten abstracts, including both company-sponsored research studies and…

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Added by Peter Hofland, PhD on May 15, 2014 at 7:30pm — No Comments

Poor Prognosis in Early Breast Cancer in Patients with CTC

Circulating tumor cells or CTCs in bone marrow of early breast cancer patients predict a higher risk of relapse as well as poorer survival. To confirm, bone marrow biopsy, an invasive and painful procedure, is generally used to identify these circulating tumor cells. But according to a new study published May 15, 2014 in the Journal of the National Cancer Institute, it may be possible to identify…

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Added by Peter Hofland, PhD on May 15, 2014 at 10:00am — No Comments

Breastfeeding and Birth Control may Help Reduce Ovarian Cancer Risk in Women with BRCA Mutations

Results from a new study conducted by researchers at the University of Pennsylvania's Basser Research Center for BRCA and the Abramson Cancer Center, the nation's only BRCA-focused research center, shows that breastfeeding, tubal ligation – also known as having one's "tubes tied" – and oral contraceptives may help lower the risk of ovarian cancer for some women with BRCA gene mutations. The findings, based on a comprehensive meta-analysis of 44 existing peer-reviewed studies, are…

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Added by Peter Hofland, PhD on May 14, 2014 at 1:30pm — No Comments

Study Results Dispel Commonly Held Beliefs about Cancer Care and Patient Demands for Treatment

Despite many claims suggesting otherwise, inappropriate demands for diagnostics and treatment by cancer patient are few and very rarely lead to unnecessary tests and treatments from their health care providers. This is the conclusion based on new results from a study that will be presented by researchers from the Abramson Cancer Center (ACC) and the Perelman School of Medicine at the University of Pennsylvania during the 50th annual meeting of the…

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Added by Peter Hofland, PhD on May 14, 2014 at 1:00pm — No Comments

Computational Model Predict Therapy Outcomes in Prostate Cancer with Bone Metastasis

Bone metastasis has shown to impact most men with advanced prostate cancer. Now a new computational model that simulates bone metastasis of prostate cancer has the potential to rapidly assess experimental therapy outcomes and help develop personalized medicine for patients with this disease, according to data published in Cancer Research, a journal of the American Association for Cancer Research (AACR).

"Bone remodeling is a balanced and extremely well regulated process that…

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Added by Editorial Team on May 1, 2014 at 10:00am — No Comments

Study Links Vitamin D Deficiency to Aggressive Prostate Cancer

Vitamin D deficiency was an indicator of aggressive prostate cancer and spread of the disease in European-American and African-American men who underwent their first prostate biopsy because of abnormal prostate-specific antigen (PSA) and/or digital rectal examination (DRE) test results, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research (AACR).[1]

"Vitamin D is a steroid hormone that is known to affect the…

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Added by Editorial Team on May 1, 2014 at 9:00am — No Comments

"Blood" Protein Implicated as a Major Player in Formation and Spread of Breast Cancer

New research suggests that Kindlin-3, a protein previously thought to be confined to the hematopoietic system, regulates 2 major hallmarks of breast cancer. This protein which was believed to be limited to the hematopoietic system, has been identified as a major player in both the formation and spread of breast cancer to other organs. This discovery, published in the May 2014 issue of…

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Added by Editorial Team on May 1, 2014 at 8:30am — No Comments

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