July 2012 Blog Posts (4)

HPV Testing Can Predict Risk of Cervical Cancer for Up to 18 Years

A study published in the online edition of the July 30, 2012 issue of the Journal of Clinical Oncology (JCO) explores the long-term benefits of human papillomavirus (HPV) DNA testing alone, cytology (Pap testing), and combinations of the two, to predict cervical precancerous disease and invasive cervical cancer risk. Based on the outcome, the researchers concluded that primary…

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Added by Peter Hofland, PhD on July 30, 2012 at 9:30pm — No Comments

New U.S. Guideline Provides Offers Evidence-based Recommendations Sentinel Lymph Node Biopsy for Melanoma Staging

The American Society of Clinical Oncology (ASCO) and the Society for Surgical Oncology (SSO) earlier today jointly issued their first evidence-based clinical practice guideline on the use of sentinel lymph node biopsy or SLNB to stage patients with newly diagnosed melanoma.…

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Added by Peter Hofland, PhD on July 9, 2012 at 6:30pm — No Comments

First Patient Dosed in Phase Ib/IIa Study of CRLX101 in Combination with Bevacizumab in Renal Cancer

Earlier this week the first patient has been dosed in a Phase Ib/IIa study of CRLX101 (formerly called IT-101, Cerulean Pharma Inc.), dual inhibitor of topoisomerase 1 and hypoxia-inducible factor-1 alpha, in combination with bevacizumab (Avastin®, Genentech/Roche) in metastatic renal cell carcinoma (mRCC) patients. Cerulean also announced the completion of enrollment of its randomized Phase II study in advanced non-small…

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Added by Peter Hofland, PhD on July 2, 2012 at 7:00pm — No Comments

Head-to-Head Comparison Trial of Carfilzomib versus Bortezomib Starts Enrolling Patients with Relapsed Multiple Myeloma

Enrollment has started for the ENDEAVOR trial , a Phase III clinical trial evaluating carfilzomib (proposed brand name Kyprolis™, Onyx Pharmaceuticals, Inc) in combination with dexamethasone, versus bortezomib (originally codenamed PS-341 and marketed as Velcade® by Millennium Pharmaceuticals) with…

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Added by Peter Hofland, PhD on July 2, 2012 at 6:00pm — No Comments

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