August 2011 Blog Posts (18)

Cryo-imaging Offers Better Way to See Tumor Cells in GBM

About half of all brain tumors diagnosed are gliomas. They usually begin in glial cells in the lobes of the upper part of the brain, but they can also grow in other areas, especially cells that surround and support nerve cells near the optic nerve, brain stem and the cerebellum.



Gliomas are tumors that contain a variety of cell types, and the distribution of each cell types varies with each tumor. The most common type of gliomas are astrocytomas. Glioblastoma… Continue

Added by Peter Hofland, PhD on August 31, 2011 at 12:30pm — No Comments

X-PECT Study of Perifosine (KRX-0401) for the Treatment of Refractory Advanced Colorectal Cancer to Proceed

An independent Data Safety Monitoring Board (DSMB) for Keryx Biopharmaceuticals' pivotal Phase III X-PECT study of Perifosine (KRX-0401) in patients with refractory advanced colorectal cancer has completed a pre-specified interim analysis for safety and futility. The independent board has recommended that the Phase III study continue to completion, as planned.



Perifosine (KRX-0401) is a novel, potentially… Continue

Added by Peter Hofland, PhD on August 31, 2011 at 6:00am — No Comments

New Drug and Companion Diagnostic Approved for a Type of Late-stage Lung Cancer Approved in U.S.

The U.S. Food and Drug Administration today approved crizotinib(Xalkori®, Pfizer), to treat certain patients with late-stage (locally advanced or metastatic), non-small cell lung cancers (NSCLC) who express the abnormal anaplastic lymphoma kinase (ALK) gene.



Crizotinib is being approved with a companion diagnostic test and is the second such targeted therapy approved by the FDA this…

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Added by Peter Hofland, PhD on August 26, 2011 at 7:30pm — No Comments

Cigarette Smokers and Heavy Alcohol Users Less Likely to Adhere to Chemoprevention Regimen in the Long Term

Women at high risk of developing breast cancer who smoked cigarettes and drank alcohol were less likely to continue with their chemopreventive regimen and may require more adherence support, according to results of a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research.



“Our results might suggest there are common factors,…

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Added by Peter Hofland, PhD on August 23, 2011 at 11:00am — No Comments

Two or More Full-term Births Put African-American Women at Higher Risk for Hormone Receptor-Negative Breast Cancer

African-American women are at higher risk for hormone receptor-negative breast cancer, one of the most difficult subtypes to treat, but this risk could be ameliorated somewhat by breast-feeding their children.



“African-American women are more likely to have had a greater number of full-term births and less likely to have breast-fed their babies,” said Julie Palmer, Sc.D., professor of epidemiology at the…

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Added by Peter Hofland, PhD on August 16, 2011 at 11:00am — No Comments

Study Shows Definitive Proof of COTI-2 Target and Single Agent Effectiveness

Results a recent clinical trial confirm that COTI-2, a novel small molecule that acts by inhibiting Akt/PKB (Protein kinase B) phosphorylation leading to caspase-9 activation in cancer cells resulting in tumor cell death, is a promising new targeted therapy candidate. The trial clearly demonstrated that COTI-2 can significantly inhibit the growth of cancer cells that over express Akt/Akt2, which is a key component of the PI3K/Akt/mTOR

signaling pathway and is involved in cell…
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Added by Peter Hofland, PhD on August 16, 2011 at 9:30am — No Comments

Poor Health in Childhood Cancer Survivors Leads to an Eightfold Higher Risk for Unemployment, Affecting Women More than Men

Childhood cancer survivors with poor physical health and neurocognitive deficits are more likely to be unemployed or work part-time in adulthood, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.



Research to date has indicated that while more children with cancer are surviving, the treatments received can…

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Added by Peter Hofland, PhD on August 15, 2011 at 11:00am — No Comments

Researchers Genetically Sequence Most Common Bladder Cancer

In an article published online this week in Nature Genetics, a University of Colorado Cancer Center team in partnership with universities in China and Denmark reports the first genetic sequencing of urothelial (transitional) carcinoma, the most prevalent type… Continue

Added by Peter Hofland, PhD on August 11, 2011 at 2:30pm — No Comments

National Call to Action on Lung Cancer Herald a Brighter Future for Patients

The New England Journal of Medicine's recent publication of the landmark National Lung Screening Trial (NLST), along with two congressional initiatives and an industry report, beacon a much brighter future for Lung Cancer patients.



Forty-three million Americans suffer from a chronic… Continue

Added by Peter Hofland, PhD on August 11, 2011 at 6:00am — No Comments

Researchers Report Genetically Modified T Cells Obliterate Tumors in Patients with CLL

In a cancer treatment breakthrough 20 years in the making, researchers from the University of Pennsylvania's Abramson Cancer Center and Perelman School of Medicine have shown sustained remissions of up to a year among a small group of advanced chronic lymphocytic leukemia (CLL) patients treated with genetically engineered versions of their own T cells.… Continue

Added by Peter Hofland, PhD on August 10, 2011 at 8:30pm — No Comments

Study Shows A Diet of Flaxseed Shows Protective Effects Against Radiation in Animal Models

Flax has been part of human history for many centuries, used for weaving cloth, feeding people and animals, and even making paint. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania have discovered that it might have a new use for the 21st century: protecting healthy tissues and organs from the harmful effects of radiation. In a study just published in… Continue

Added by Peter Hofland, PhD on August 9, 2011 at 8:00pm — No Comments

Oncogenic Tyrosine Kinase NPM-ALK Silencing of the IL-2Rγ gene Suggest a New Target for Lymphoma

Mariusz A. Wasik, MD, professor of Pathology and Laboratory Medicine, and Qian Zhang, MD, PhD, research assistant professor, both from the Perelman School of Medicine at the University of Pennsylvania, and their colleagues, found that a cancer-causing fusion protein works by silencing the tumor suppressor gene IL-2R common gamma-chain (IL-2Rγ). The results, which appeared… Continue

Added by Peter Hofland, PhD on August 9, 2011 at 6:30pm — No Comments

Long-Term Raloxifene Treatment in Postmenopausal Osteoporosis Shows Reduction of Invasive BC

Data on long-term therapy with raloxifene HCl (Evista®, Eli Lilly and Company )for more than three years was published online in Current Medical Research & Opinion. Raloxifene is an estrogen agonist/antagonist, commonly referred to as a selective estrogen receptor modulator (SERM), which appears… Continue

Added by Peter Hofland, PhD on August 9, 2011 at 5:30pm — No Comments

Minimally Invasive Approach to Remove Thyroid Tumors Eliminates Neck Scar

As the rate of thyroid cancer continues to climb, doctors are urging patients to be more cautious about thyroid nodules, a common disorder that is responsible for a small but growing number of thyroid cancer cases. Thyroid nodules affect nearly 13 million Americans and are a result of… Continue

Added by Peter Hofland, PhD on August 9, 2011 at 8:30am — No Comments

TrueBeam® and RapidArc® Radiotherapy Systems better in Sparing Healthy Tissues and Organs

Medical physicists meeting at the 2011 Joint Meeting of The American Association of Physicists in Medicine (AAPM) and the Canadian Organization of Medical Physicists (COMP) in Vancouver, BC (Canada) report that RapidArc® radiotherapy treatment plans(Varian Medical… Continue

Added by Peter Hofland, PhD on August 9, 2011 at 5:00am — No Comments

Nonsteroidal Anti-inflammatory Drugs May Help Reduces Severity of Postpartum Breast Cancers

The prognosis of breast cancer in young women is strongly influenced by their reproductive history. Women diagnosed within 5 years postpartum, for example, generally have a worse prognosis than nulliparous women or women diagnosed during pregnancy.In an article published online in journal Nature Medicine (Aug. 7, 2011) researchers reports that nonsteroidal anti-inflammatory drugs(NSAIDs)… Continue

Added by Peter Hofland, PhD on August 7, 2011 at 4:30pm — No Comments

Research Suggests Safer CT Scans Possible when Factoring In Patient Age, Gender and Size

New software aimed at making computed tomography (CT) safer for patients estimates the radiation risk based on age, gender and size rather than using the current “one size fits all” approach. The software program, tested on more than 6,500 scans, was introduced today at the 2011 Joint Meeting of the American Association of Physicists in Medicine (AAPM) and Canadian… Continue

Added by Peter Hofland, PhD on August 4, 2011 at 6:30pm — No Comments

Early Reserach Suggest Gold Nanoparticles May Help Deliver One-Two Punch to Cancer

Microscopic gold particles could multiply the effectiveness of standard cancer radiation therapy by acting as tiny missiles that destroy blood vessels feeding cancerous tumors. Early research about this method, which could shorten cancer treatment and make it more effective, is being presented today at the 2011 Joint Meeting of the American Association of Physicists in Medicine (… Continue

Added by Peter Hofland, PhD on August 4, 2011 at 6:30pm — No Comments

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