August 2013 Blog Posts (42)

Epigenetic Factors Play a Role in Cell Senescence - Affecting Gene Expression, Aging and Cancer

Cells can promote tumor suppression via a process of irreversible arrest of proliferation called senescence. This process is thought to be associated with normal aging, but is also a protective measure against run-away cell replication. Studying the basic science of senescence gives biomedical researchers a better understanding of the mechanisms behind age-related diseases such as cancer.

Scientists from the…

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Added by Editorial Team on August 30, 2013 at 4:00pm — No Comments

Study Shows Expression of Polycomb Targets may Accurately Predict Breast Cancer Prognosis and Progression

Researchers from the Unit on Biomedical Informatics, Department of Experimental and Health Sciences, Universitat Pompeu Fabra in Barcelona, Spain, have identified a protein that they believe may help predict breast cancer prognosis.  According to the researchers, this finding may potentially relieve thousands of women at low risk for breast cancer from having to undergo painful, often debilitating therapies, while insuring the most…

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Added by Editorial Team on August 29, 2013 at 4:00pm — No Comments

Study Shows New Imaging Technology May Help Improve Patient Care for Several Types of Cancer

Researchers from University Hospitals Case Medical Center working in collaboration with researchers from Philips Healthcare, have found that a new form of imaging called PET/MRI, provided added value in the diagnosis, staging and treatment planning of colorectal cancers, cervical, uterine, ovarian and pancreatic cancers. The new technology also improved the diagnostic management of pediatric and young adult patients.

The findings are published in the September 2013 issue of…

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Added by Editorial Team on August 29, 2013 at 1:30pm — No Comments

Novel Strategy May Offer an Effective Treatment Option for High-risk Acute Lymphoblastic Leukemia

Scientists at St. Jude Children’s Research Hospital in Memphis, Tennessee (USA), have identified a protein that certain high-risk acute lymphoblastic leukemia (ALL) cells need to survive and have used that knowledge to develop a two-drug combination therapy that offers a more effective method of killing tumor cells. In doing so, they have give new hope to children and adults with the disease. The findings appear in the August 29, 2013 online edition of the journal…

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Added by Editorial Team on August 29, 2013 at 10:30am — No Comments

Researchers find Critical Role of NOTCH 1 in Many Lung Cancer Cases

Scientists from the Florida campus of The Scripps Research Institute (TSRI), one of the world's largest independent, not-for-profit organizations focusing on research in the biomedical sciences, have shown that a well-known cancer-causing gene, Notch 1, implicated in a number of malignancies plays a far more critical role in non-small cell lung cancer (NSCLC), the most common form of the disease, than previously thought.

The Notch signaling network is an intercellular…

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Added by Editorial Team on August 29, 2013 at 8:00am — No Comments

Large Study Confirms Link Between School-age Alcohol Consumption and Breast Cancer

It's a real sobering fact for millions of young women heading back to school or college. Researcher have found a link confirming that alcohol consumption before motherhood increases their risk of future breast cancer.

The conclusions stem from new research conducted by researchers at the Washington University School of Medicine in St. Louis that, for the first time, links increased breast cancer risk to alcohol consumption between early adolescence and first…

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Added by Editorial Team on August 28, 2013 at 2:30pm — No Comments

Recommended Daily Doses of Calcium and Vitamin D Supplements May Not Prevent Loss of Bone Mineral Density in Women With Breast Cancer

One of the unintended consequences of breast cancer therapies is an increased risk of osteoporosis due to accelerated bone loss. To offset this unwanted side effect, women undergoing breast cancer treatment cancer are widely prescribed calcium and vitamin D supplements to prevent and manage osteoporosis. However, new research from Wake Forest Baptist Medical Center finds that the recommended daily doses of these supplements may not…

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Added by Editorial Team on August 27, 2013 at 9:30pm — No Comments

Protein Found in Nearly all High-grade Meningiomas may be Promising Therapeutic Target

Researchers at Johns Hopkins Medicine (JHM) in Baltimore, Maryland (USA), say they have found a specific protein in nearly 100% of high-grade meningiomas, suggesting a new target for therapies for a cancer that does not respond to current chemotherapy.

According to the Central Brain Tumor Registry of the United States (CBTRUS), high-grade meningiomas are the most common form of brain tumor - making up about 34% of all primary brain tumors. [1] They form from…

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Added by Editorial Team on August 27, 2013 at 9:30pm — No Comments

Classification of Gastric Cancer Subtypes May Help Development of Different Treatment Approaches

According to researchers at Duke-NUS Graduate Medical School in Singapore, stomach or gastric cancer is a heterogeneous disease which falls into three broad subtypes with distinct biological properties and effects that respond differently to currently available therapies.

Understanding these research findings may help improve patient care. The researchers expect that the development of a genetic test designed to…

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Added by Editorial Team on August 27, 2013 at 4:00pm — No Comments

Blood Test Used to Detect Recurrence of Ovarian Cancer Uncovers Invasive, High-grade Disease at Curable Stage

According to researchers at The University of Texas MD Anderson Cancer Center, evaluating change over time of carbohydrate antigen 125 or CA-125, the protein long-recognized for predicting ovarian cancer recurrence, shows promise as a screening tool for early-stage disease.  CA-125,  a protein that is a so-called tumor marker or biomarker, is present in greater concentration in ovarian cancer cells than in other cells.

The findings showing a potential benefit in early…

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Added by Editorial Team on August 26, 2013 at 10:30pm — No Comments

Too Much Coffee Kills You.... or Not?

Is a cups of coffee good or bad for your health? This issue has been examined by many studies and this month two interesting studies try again to present the facts.

The first study published in the August 19 online edition of Mayo Clinic Proceedings [1] suggests that drinking more than 28 cups of coffee a week – an average of four cups a day – may lead to an increased risk of all cause mortality. In other words, too much coffee might be a potential killer. The…

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Added by Editorial Team on August 26, 2013 at 9:00am — No Comments

Interleukin-7 (IL-7) May Enhance Lymphatic Drainage - Offering a Potential Treatment for Lymphedema Patients

The multifunctional cytokine Interleukin-7 (IL-7) is an important immune messenger protein which ensures that a sufficient number of T-cells are present in our body for immune defense. IL-7 is mainly produced by non-hematopoietic cells, including stromal cells in the bone marrow and thymus. The hematopoietic growth factor is also produced by keratinocytes, fetal liver, adult liver, dendritic cells, hepatocytes, neurons, and epithelial cells but not by normal lymphocytes.

IL-7…

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Added by Editorial Team on August 26, 2013 at 7:30am — No Comments

New Molecular Mechanism Tied to Pancreatic Cancer

Scientists at The University of Texas Health Science Center at Houston (UTHealth) and Baylor College of Medicine may soon succeed in diagnosing and treating pancreatic cancer, one of the most lethal and hard-to-treat types of cancer.

The investigators report in the an article published in the July 16 online edition EMBO Molecular Medicine that they have identified a new molecular…

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Added by Editorial Team on August 22, 2013 at 8:30pm — No Comments

Link between Stress and Cancer: 'Master-Switch' Turns Our Own Bodies Against Us

In an unexpected finding, scientists have linked the activation of a stress gene in immune system cells to the spread of breast cancer to other parts of the body. Researchers say the study suggests this gene, called ATF3, may be the crucial link between stress and cancer, including the major cause of cancer death – its spread, or metastasis. Previous public health studies have shown that stress is a risk factor for cancer. The findings were published in the July 1, 2013 edition of the…

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Added by Editorial Team on August 22, 2013 at 8:30pm — 1 Comment

Cutting Calories May Improve Response to Cancer Treatment

Restricting calories for a defined period of time may improve the success of cancer treatment. This is one of the conclusions in a study published today in the online edition of Blood, the Journal of the American Society of Hematology (ASH).[1]

The results of this study offer valuable new data on how caloric intake may play a role in programmed cancer cell death and efficacy of targeted cancer therapies.

Limited data

Although previous studies…

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Added by Editorial Team on August 21, 2013 at 10:00pm — No Comments

Study Examines Link Between Oral Health Oral Cancer-causing HPV Infection

Results of a recent study published in August 21, 2013 online edition of Cancer Prevention Research, a journal of the American Association for Cancer Research, shows that poor oral health, including gum disease and dental problems, was found to be associated with oral human papillomavirus (HPV) infection.[1]

Commenting on the…

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Added by Editorial Team on August 21, 2013 at 10:00am — No Comments

Pilot Study Shows that Chemotherapy before Radiotherapy may Reduce Long-term Side-effects in Men with Testicular Cancer

It is estimated that as many as 96% of men with testicular cancer survive at least ten years from diagnosis [1], but more advanced forms need to be treated with combination chemotherapy – which can have serious long-term complications. To reduce these long-term complications, researchers have been searching for new treatments that would reduce the risk of relapse after initial treatment and so spare as many men as possible from needing combination chemotherapy.

Researchers at…

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Added by Editorial Team on August 16, 2013 at 7:30am — No Comments

Small Molecule Inhibitor of the DOT1L Histone Methyltransferase (HMT) for Acute Leukemias with MLL Rearrangements (MLL-r) gets Orphan Drug Designation

The Food and Drug Administration has granted an Orphan drug designation to EPZ-5676, a small molecule inhibitor of DOT1L for the treatment of acute leukemias in which the MLL (ALL1) gene, located at 11q23, is rearranged due to a chromosomal translocation (MLL-r).

Due to the translocation, DOT1L is recruited to specific locations in the chromosome where it would not normally be present. As a result, DOT1L causes inappropriate methylation at these locations, which results in…

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Added by Editorial Team on August 16, 2013 at 5:30am — No Comments

AMF-1c-120 Administered to Live Animals Targets and Binds to Tumors in a Very Localized and Concentrated Manner, Study Shows

Results of recent pre-clinical studies with AMF-1c-120 (Amorfix Life Sciences, Ltd) shows that this proprietary anti-ovarian cancer antibody, when administered to live animals, targets and binds to tumors in a very localized and concentrated manner. This is a significant finding because it shows that the antibody retains its tumor-specific binding in vivo.

As part of the pre-clinical study, cancer cells were…

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Added by Editorial Team on August 14, 2013 at 6:30am — No Comments

Necitumumab Meets Primary Endpoint of Overall Survival Survival in Patients with Stage IV Squamous NSCLC

The recently completed SQUIRE study, a randomized, multicenter, open-label phase III study of gemcitabine-cisplatin chemotherapy plus necitumumab (IMC-11F8; Eli Lilly & Co/ImClone) versus gemcitabine-cisplatin chemotherapy alone in the first-line treatment of patients with stage IV squamous non-small cell lung cancer (NSCLC) met its primary endpoint. The study result showed…

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Added by Editorial Team on August 13, 2013 at 5:30pm — No Comments

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