September 2011 Blog Posts (32)

New Study Connects Cancer and Diabetes: Pathway Influences Cellular Response to Glucose

A pathway activated in cancer plays an unexpected key role in metabolic diseases like T2DM (type 2 diabetes), according to a study by researchers at Children's Hospital Boston. Evidence that the Lin28/let-7 pathway influences the cellular response to glucose provides a unifying theme to perplexing data that associates human genetic variation with diabetes risk.



The multi-institutional research… Continue

Added by Peter Hofland, PhD on September 29, 2011 at 11:00am — No Comments

Britsh Study Confirms Link Between Fatalism, Poor Self-Rated Health and Socioeconomic Status

A study in England demonstrated that, despite significant advances in science, medicine, and technology, socioeconomic status has a major impact on the acceptance of cancer screening. The study showed that even if health care is free, colorectal cancer screening rates among those without financial means are still low, and results of a new study suggest that may be due to an idea psychologists call cancer fatalism.[1]



The belief that death is inevitable when…

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Added by Peter Hofland, PhD on September 27, 2011 at 11:00am — No Comments

Inflammation Marker may Allow for a More Precise Prognosis Prostate Cancer

Today, current methods of prostate cancer detection, such as the prostate-specific antigen (PSA) test, often fail to identify which cancers will prove fatal and which cancers will remain benign until a patient dies of other causes.



“We are in need of better markers that distinguish between aggressive and indolent disease in this population,” said Jennifer R. Rider,…

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Added by Peter Hofland, PhD on September 27, 2011 at 11:00am — No Comments

Pemetrexed Study Shows Benefit in Elderly Patients with the Most Common Form of Lung Cancer

A new subgroup analysis of data from the pivotal Phase III PARAMOUNT study showed that continuation maintenance therapy with pemetrexed for injection (Alimta®, Eli Lilly and Company) also reduces the risk of disease progression in patients aged 70 years or older with advanced nonsquamous non-small cell lung cancer (NSCLC), the most common type of lung cancer.… Continue

Added by Peter Hofland, PhD on September 26, 2011 at 10:00am — No Comments

Women With Advanced Breast Cancer Live Significantly Longer When Treated with Everolimus

A pivotal Phase III study shows everolimus tablets (Afinitor®, Novartis) plus exemestane, a hormonal therapy, more than doubled the time women lived without tumor growth (progression-free survival; PFS) and significantly reduced the risk of cancer progression by 57% versus exemestane (Aromasin®, Pfizer) alone in patients with advanced breast cancer [1].… Continue

Added by Peter Hofland, PhD on September 25, 2011 at 3:30pm — No Comments

Antibody-drug Conjugate for MBC Highlights Importance of Personalised Approach to Cancer Care

Results of the first randomised phase II study, known as TDM4450g, in patients with previously untreated HER2-positive metastatic breast cancer (mBC) were presented today at the 2011 European Multidisciplinary Cancer Congress in Stockholm.

Breast cancer is the most common cancer among women worldwide. Each year about 1.4 million new cases of breast cancer are diagnosed worldwide and over 450,000 people will die of the disease annually.[1] In HER2-positive breast cancer,…

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Added by Peter Hofland, PhD on September 25, 2011 at 2:30pm — No Comments

Researchers Discovers Genetic Risk Factor for Skin, Prostate and Brain Cancers

Scientists at deCODE Genetics, a specialist company focused on analyzing and understanding the human genome, and academic collaborators from Iceland, The Netherlands, Spain, Denmark, Germany, Sweden, the USA, the UK and Romania today report the discovery of a variant in the sequence of the human genome associated with risk of developing basal cell carcinoma of the skin (BCC), as well as prostate cancer and glioma, the most serious… Continue

Added by Peter Hofland, PhD on September 25, 2011 at 10:30am — No Comments

Breakthrough Cancer Pain Initiative: Identification and Management Remains a Challenge

The the first European survey to look at oncology nurse perception of breakthrough cancer pain and its management calls for greater clinical consensus and new guidelines on diagnosis and treatment of breakthrough cancer pain.



The results of the survey were presented today at the European Multidisciplinary Cancer Congress being held from September 23 – 27, in Stockholm, Sweden. The survey was performed for the… Continue

Added by Peter Hofland, PhD on September 24, 2011 at 7:00am — No Comments

Majority of Pediatric Patients with Hodgkin Lymphoma Achieve CR After Treatment with Brentuximab

Six out of nine pediatric patients with relapsed or refractory Hodgkin lymphoma (HL) (n=5)or systemic anaplastic large cell lymphoma (sALCL) (n=4)achieved complete remission (CR) in multicenter phase I and phase II trials of Brentuximab Vedotin ( SGN-35 and previously called cAC10-vcMMAE; now marketed as Adcetris™ by Millennium: The…

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Added by Peter Hofland, PhD on September 24, 2011 at 5:30am — No Comments

Radium-223 Chloride Shows Significant Increase in OS in CRPC and Symptomatic Bone Metastases

Data presented as part of Presidential Session featuring best and late-breaking abstracts at 2011 European Multidisciplinary Cancer Congress reveals that the investigational drug radium-223 chloride (Alpharadin, Bayer HealthCare Pharmaceuticals and Algeta ASA) showed positive results in the Phase III ALSYMPCA (ALpharadin in SYMptomatic Prostate CAncer) trial.… Continue

Added by Peter Hofland, PhD on September 24, 2011 at 3:30am — No Comments

Updated Efficacy Results From Phase III Trial Confirm Strong Treatment Effect of Chemosaturation

Updated investigator results from the Phase II randomized trial of Delcath's chemosaturation system with melphalan in patients with hepatic metastases from ocular or cutaneous melanoma, presented by James F. Pingpank, MD, FACS, Associate Professor of Surgery at the University of Pittsburgh School of Medicine during the plenary session at the European Multidisciplinary Cancer Congress (EMCC) in Stockholm, shows increased hepatic… Continue

Added by Peter Hofland, PhD on September 23, 2011 at 3:30pm — No Comments

Researchers Identify Cellular Origin of a Rare Form of Breast Cancer

Identifying the cellular origins of breast cancer might lead to earlier diagnosis and more efficient management of the disease. New research led by Charlotte Kuperwasser, PhD, associate professor in the department of anatomy and cellular biology, Tufts University School of Medicine (TUSM), and a member of the genetics and cell, molecular & developmental program faculties at the Sackler School of Graduate Biomedical Sciences… Continue

Added by Peter Hofland, PhD on September 23, 2011 at 12:30pm — No Comments

Bevacizumab Receives Positive Opinion from Europe in Newly Diagnosed Advanced Ovarian Cancer

The European Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for the use of Bevacizumab (Avastin, Genentech/… Continue

Added by Peter Hofland, PhD on September 23, 2011 at 12:30am — No Comments

Risk for Vitamin D Deficiency in African-American Men Living in Poor Sunlight

African-American men living in low sunlight areas are more likely to experience vitamin D deficiency than European-American men living in the same environment. Researchers believe that these  findings should change recommendations for…

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Added by Peter Hofland, PhD on September 20, 2011 at 11:00am — No Comments

Prediabetes or Gestational Diabetes Could Speed Up Development Cancer - Simple Diagnostic Test Can Help

Certain cancer signaling pathways that are activated in aggressive cancer can be detected very early, even in precancerous cells, among young African-American women at high risk for breast cancer. This may allow for earlier detection and prevention of cancer.



However, the early activation of these pathways, which are linked to how the body’s cells consume and break down sugar, also raise the concern that certain conditions such as gestational diabetes and…

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Added by Peter Hofland, PhD on September 20, 2011 at 11:00am — No Comments

Genetic Difference Could Explain Higher Rates of Prostate Cancer and Mortality in African-American Men

Genetic differences in prostate cells seem to be a root cause of the prostate cancer disparities between African-American men and white men, according to findings presented at the Fourth AACR Conference on The Science of Cancer Health Disparities, held in Washington DC, September 18-21, 2011.



Prostate cancer is the second most common cancer among U.S. men, with occurrences and mortality rates higher in African-American men compared to white men. “There are…

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Added by Peter Hofland, PhD on September 20, 2011 at 11:00am — No Comments

Deaths from Acute Leukemia Higher in Blacks and Hispanics - Researchers Suspect Socioeconomic Factors

Blacks and Hispanics have fewer cases of acute leukemia compared to whites but they die at a substantially higher rate, according to study results presented at the Fourth AACR Conference on The Science of Cancer Health Disparities, held in Washington DC, September 18-21, 2011.



From 1998 to 2008, blacks had a 17% increased risk of dying from acute leukemia and Hispanics had a 12% increased risk compared to white patients. When separated into the two forms of…

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Added by Peter Hofland, PhD on September 19, 2011 at 11:00am — No Comments

Association Found Between Fear, Anxiety and Isolation and Agressive Breast Cancer

Psychosocial stress could play a role in the etiology of breast cancer aggressiveness, particularly among minority populations, according to study results presented at the Fourth AACR Conference on The Science of Cancer Health Disparities, held in Washington DC, from September 18-21, 2011.



“We found that after diagnosis, black and Hispanic breast cancer patients reported higher levels of stress than whites, and that stress was associated with tumor…

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Added by Peter Hofland, PhD on September 19, 2011 at 11:00am — No Comments

Regardless of Age, Higher Incidence of Secondary Breast Cancer Among Black Women; Overall Incidence of Breast Cancer Higher Among White Women

The overall incidence of breast cancer is generally higher among white women than black women; however, the incidence of a second breast cancer in the opposite breast is higher among black women, according to a study presented at the Fourth AACR Conference on The Science of Cancer Health Disparities, held in washington DC, September 18-21, 2011.



When cancer is diagnosed in women younger than 45 years old, the incidence of primary breast cancer is higher…

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Added by Peter Hofland, PhD on September 19, 2011 at 11:00am — No Comments

Depression Linked to Ovarian but not Colorectal Screening Noncompliance Among Latina Breast Cancer Survivors

Depression, in addition to other barriers, may prevent Latina breast cancer survivors from undergoing preventive health screening for colorectal and ovarian cancer, according to data presented at the Fourth AACR Conference on The Science of Cancer Health Disparities, held in Washington DC, September 18-21, 2011.



“Depression can make people more inattentive to potential risks to their health and more likely to ignore recommendations to reduce their risk,”…

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Added by Peter Hofland, PhD on September 19, 2011 at 11:00am — No Comments

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