November 2013 Blog Posts (17)

New Mechanism Promoting Breast Cancer: Cyclin D1 controls cell cycle progression and microRNA biogenesis through Dicer

According to new research published in the November 29, 2013 edition of Nature Communications, a protein called Cyclin D1 (G1/S-specific cyclin-D1 or CCND1) which helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA (miRNA).

The research suggests that Cyclin D1 which is strongly implicated in human cancer, also governs the non-protein-coding genome. The non-coding genome, previously referred to as junk…

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Added by Editorial Team on November 29, 2013 at 1:30pm — No Comments

How Cholesterol is Fueling the Growth and Spread of Breast Cancer

A new study published in the November 29, 2013 edition of the journal Science, sheds new light on a woman's risk of developing breast cancer. The study, for the first time, explains the reason behind the established relationship between high cholesterol and breast cancer -- especially in obese women who have reached menopause.[1]

Researchers from Duke Cancer Institute in North Carolina found that a primary…

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Added by Editorial Team on November 28, 2013 at 4:00pm — No Comments

Over-regulation of Opioid Analgesics Makes it Catastrophically Difficult to Provide Basic Medication to Relieve Strong Cancer Pain

Many patients around the globe do not have access to proper opioid analgesics - critical to the effective relief and management of cancer pain. This lack of access represent a serious public health problem. These conclusions are from the Global Opioid Policy Initiative (GOPI) project, a ground-breaking international collaborative survey which show that more than 4 billion people live in countries where regulations designed to to stem drug misuse, leave cancer patients suffering…

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Added by Editorial Team on November 27, 2013 at 6:30pm — No Comments

Women with a Negative Test for Family-specific BRCA2 Mutation may still have Increased Risk for Developing Breast Cancer

According to results from a recent study published in the November 27, 2013 online edition of Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, women who are members of families with BRCA2 mutations but who test negative for the family-specific BRCA2 mutations are still at greater risk for developing breast cancer compared with women in the general population.[1]

Women with certain mutations in their BRCA1 or BRCA2…

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Added by Editorial Team on November 27, 2013 at 3:30pm — No Comments

Preview of 55th ASH® Annual Meeting, New Orleans, LA

The American Society of Hematology or ASH® is the preeminent professional society concerned with the causes and treatments of blood disorders.  This year the society will have their Annual Meeting from December 7 to 10 in New Orleans, Louisiana. During this meeting - the organizers expect more than 20.000 attendees from more than 100 countries to attend - exciting clinical studies and updates affecting the daily clinical practice will be presented.

"The Science of blood is…

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Added by Editorial Team on November 27, 2013 at 10:00am — No Comments

Eating a High-fat Diet at Early Puberty may Speed up Breast Cancer Development

Researchers involved in epidemiological studies looking at the potential contributions to breast cancer risk have not been able to provided conclusive evidence linking dietary fat intake and obesity to breast cancer risk. In the pooled analysis of data from large, prospective cohort studies, high BMI (≥25 kg/m2) was a recognized risk factor for postmenopausal breast cancer [1]. Conversely, in the same analysis, high BMI (>31) is associated with reduced risk for premenopausal breast…

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Added by Editorial Team on November 26, 2013 at 9:00pm — No Comments

Poor Prognosis Predicted in Patients Experiencing Symptom Clusters after Surgery for Esophageal Cancer

A new study from Sweden has found that several months after surgery for esophageal cancer, different symptoms cluster together in different types of patients. In addition, patients with certain symptom clusters have an increased risk of dying from their disease. The findings are published in the November 25, 2013 online edition of Cancer, a peer-reviewed journal published by the American Cancer Society (ACS).[1]

Esophageal cancer is an aggressive cancer with a very poor…

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Added by Editorial Team on November 25, 2013 at 10:00pm — No Comments

PRECEDENT Trial of Vintafolide in Platinum-Resistant Ovarian Cancer Basis for European Regulatory Application

Based on trial results from the randomized Phase II PRECEDENT trial for vintafolide (MK-8109/EC145; Merck and Endocyte), an investigational folate small molecule drug conjugate or SMDC, published in the Journal of Clinical Oncology (JCO), the official journal of the American Society of Clinical Oncology, a regulatory application is currently under review with the…

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Added by Editorial Team on November 14, 2013 at 5:00pm — No Comments

New Trigger for Breast Cancer Metastasis Identified by Penn State Researchers

For many years, scientists have observed that breast tumor from certain breast cancer patients with aggressive - metastatic - undergo epithelial-to-mesenchymal transition or EMT which makes them resistant to therapies targeted to the primary cancer. They also observed that breast cancer contained low levels of mitochondrial DNA or mtDNA. However, until recently, the mechanistic link between mtDNA reduction, often seen in breast cancer patients, and EMT was unknown. No one was able to…

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Added by Editorial Team on November 8, 2013 at 12:00pm — No Comments

CLL11 Shows that Obinutuzumab plus Chlorambucil Improves Overall Survival Compared to Chlorambucil Alone

Positive data from the second stage of the phase III CLL11 trial, conducted in cooperation between Roche and the German CLL Study Group, compared obinutuzumab (Gazyva™, Genentech/Roche), a glyco-optimised type II CD20 blocker also known as GA101, in combination with chlorambucil to rituximab (Rituxan®, Genentech/Roche) in combination with chlorambucil for people with previously untreated chronic lymphocytic leukemia (CLL) and co-existing medical conditions. The data showed that people…

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Added by Editorial Team on November 8, 2013 at 7:00am — No Comments

Consumption of Tree Nuts Associated with Reduced Risk of Pancreatic Cancer in Women

In a large prospective study published online in the October 22, 2013 issue of the British Journal of Cancer (BMJ), researchers looked at the association between nut consumption and risk of pancreatic cancer among 75,680 women in the Nurses' Health Study, with no previous history of cancer. Consumption of nuts, including…

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Added by Editorial Team on November 8, 2013 at 1:00am — No Comments

Study Shows that Less-invasive -- Minimally Invasive Endoscopic Procedures -- are as Effective as Esophagus Removal in Early Esophageal Cancer

A minimally invasive endoscopic procedure to remove superficial, early stage esophageal cancer is as effective as surgery that takes out and rebuilds the esophagus, according to a study by researchers at Mayo Clinic in Florida, USA, The research, published in the November issue of Clinical Gastroenterology and Hepatology, examined national outcomes from endoscopic treatment compared to esophagectomy, surgical removal of the esophagus.

It found that endoscopic therapy offered…

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Added by Editorial Team on November 7, 2013 at 2:00pm — No Comments

Researchers Identify Role of Cul4 Molecule in Genome Instability and Cancer

Researchers at the Mayo Clinic have shown that a molecule called Cul4 helps to deposit DNA-packaging histone proteins onto DNA, an integral step in cramming yards of genetic code into compact coils that can fit into each cell. When DNA isn't packaged correctly, it can lead to the genomic instability characteristic of many forms of cancer

The research is published in the November 7, 2013 issue of the journal Cell. [1] The results explain on a molecular level how Cul4…

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Added by Editorial Team on November 7, 2013 at 1:30pm — No Comments

Nanoparticles from Biodegradable Plastics can Overcome Drug Resistance in Treatment of Breast Cancer

Resistance to treatment with chemotherapeutic drugs is a major complication in clinical oncology and is one of the most common treatment limitations in patients with reoccurring cancers. Researchers have developed nanoparticle (NP)-based drug delivery systems designed to overcome drug resistance in cancer cells mainly by avoiding the activation of efflux pumps in these cells. According to a study published in the scientific journal Biomaterials, these nanoparticles filled with…

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Added by Editorial Team on November 7, 2013 at 1:30pm — No Comments

Special Camera Detects Tumors - Displays Fluorescent Molecules that "Paint" the Cancer Tissue

Patients with cancer have the highest probability of recovering if tumors are completely removed. However, some tiny clusters of cancer cells may be difficult recognize and remove. Now a new camera makes hidden tumors visible during surgery, helping surgeons improve their patients survival.

Tumor removal surgeries pose a great challenge even to skillful and experienced surgeons. Often, tumor margins are blending into healthy tissue and are difficult to differentiate.…

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Added by Editorial Team on November 7, 2013 at 11:00am — No Comments

New Online Course Helps Physicians Improve Skills in Detecting Skin Cancer

With increasing incidence and mortality of melanoma, better recognition and management by primary care providers (PCPs) becomes more important. Historically, studies suggest PCPs would benefit from additional education leading to effective early detection which is still the best hope for cutting melanoma deaths by at least half in the near future.

According to a new national study from Henry Ford Hospital in…

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Added by Editorial Team on November 7, 2013 at 9:30am — No Comments

The War on Cancer: From Promises Made by President Nixon Until Now

Finding a cure for cancer - the second-leading cause of death in the United States - was what the American people really wanted in 1970. In response, President Nixon, in the January 1971 State of the Union address said: "I will also ask for an appropriation of an extra $100 million to launch an intensive campaign to find a cure for cancer, and I will ask later for whatever additional funds can effectively be used. The time…

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Added by Peter Hofland, PhD on November 4, 2013 at 10:00pm — No Comments

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