Peter Hofland, PhD's Blog Posts Tagged 'Chemotherapy' (18)

Study Shows Better Outcomes for Young Women With Triple-negative and Luminal-type Breast Cancer; More Likely Than Older Women to Respond to Neoadjuvant Chemotherapy

Women with breast cancer aged 35 or younger were more likely than older women to achieve a pathological complete response after neoadjuvant chemotherapy, according to data presented at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium, held December 4-8 in san Antonio, Texas.

“Young women with breast cancer are rare, and some data indicate that their prognosis is worse than it is for older women,” said…

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Added by Peter Hofland, PhD on December 6, 2012 at 2:30pm — No Comments

Standard Treatment of Head and Neck Squamous Cell Carcinoma Less Effective in HIV-positive Patients



Radiation therapy with or without chemotherapy is less effective for patients with HIV when compared to the recurrence and overall survival rates in patients who do not have HIV, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, held from January 26-28, 2012 in the Biltmore, Phoenix, Arizona.



Treating head and neck cancer in HIV-positive patients is a challenge for oncologists. Because of the advancements in… Continue

Added by Peter Hofland, PhD on January 26, 2012 at 11:30am — No Comments

Gemtuzumab Ozogamicin (GO) + Standard Chemotherapy (CT) Improve Event-Free and Overall Survival in Newly-Diagnosed De Novo AML Patients Aged 50-70 Years Old

Research over the last several decades has helped deliver improved therapeutic options for patients suffering from leukemia, a condition that still remains lethal. New options to help diagnose the condition earlier and new therapies that will extend patients’ lives are needed. Research from a number of major studies addressing important updates on the diagnosis and treatment of leukemia were presented at the 53rd Annual Meeting of…

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Added by Peter Hofland, PhD on December 10, 2011 at 10:30am — No Comments

Researchers Try to Find Better Ways to Assess Early Cardiac Injury from Chemotherapy Used to Treat Breast Cancer

Researchers are studying to see if they can determine sooner whether the drug doxorubin (Adriamycin®/Doxil®) – often called the red stuff by patients because of its ruby red color – might cause long-term damage to breast…

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Added by Peter Hofland, PhD on December 4, 2011 at 5:30pm — No Comments

Acute Myeloid Leukemia Patients May Receive Unnecessary High Doses Chemotherapy

Patients with acute myeloid leukemia (AML), a cancer of the blood and bone marrow which is also called acute myelogenous leukemia or acute myeloblastic leukemia, receive ten times more chemotherapy than necessary. This was revealed by a team of Dutch hematologists at the 16th Congress of the European Hematology Association in London.



Commenting on these findings,Bob Löwenberg, Professor of Hematology at the… Continue

Added by Peter Hofland, PhD on June 10, 2011 at 7:00pm — No Comments

New Regimen with High-Dose Chemotherapy Improves Survival Hard-to-Treat Pediatric Neuroblastoma

A randomized Phase III trial conducted by researchers of the University of Vienna and St. Anna Children’s Cancer Research Institute Vienna, Austria, showed that children with high-risk neuroblastoma, the most common extracranial solid tumor in infancy, had better event-free and overall survival with a combination of the myeloablative…

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Added by Peter Hofland, PhD on June 5, 2011 at 10:30am — No Comments

Semuloparin in Patients Initiating Chemotherapy Shows a 64% Risk Reduction in Life-Threatening VTE

Results of the pivotal phase III SAVE-ONCO study [1] for Sanofi-Aventis' Semuloparin demonstrate that, in cancer patients initiating a chemotherapy regimen, the investigational drug significantly reduced the risk of the composite of symptomatic-deep vein thromboembolism (DVT), non-fatal pulmonary embolism (PE) or venous thromboembolism (VTE)-related death by 64% [1], meeting the study primary endpoint (respectively 1.2% and… Continue

Added by Peter Hofland, PhD on June 4, 2011 at 5:30am — No Comments

Titan Study Shows Erlotinib to be as Effective as Chemotherapy in Patients Whose Disease Progressed After First-line Treatment

The targeted cancer drug erlotinib Tarceva®, Genentech/OSI Oncology) has comparable efficacy to chemotherapy, and is better tolerated, in hard-to-treat cases where a patient’s cancer has progressed quickly after treatment with first-line therapy, the results of a new phase III trial show.



Tudor Ciuleanu, M.D., from the Institute of Oncology Ion Chiricuta,… Continue

Added by Peter Hofland, PhD on February 26, 2011 at 11:30am — No Comments

Bevacizumab-based Regimen in Recurrent, Platinum-sensitive Ovarian Cancer Meets Primary Endpoint

Results from the OCEANS Study, a phase III study evaluating bevacizumab (Avastin®, F. Hoffmann-La Roche Ltd) in combination with chemotherapy (carboplatin and gemcitabine) followed by continued use of bevacizumab alone until disease progression in women with previously treated (recurrent), platinum-sensitive ovarian cancer, met its primary endpoint.



OCEANS… Continue

Added by Peter Hofland, PhD on February 8, 2011 at 11:30am — No Comments

Positron Emission Tomography (PET) Detected Responses to Chemotherapy Help to Determine Prognosis in Rare Esophageal Cancer

A prospective study, MUNICON II, has shown that detecting early metabolic response to chemotherapy by positron emission tomography (PET) imaging prior to surgery is useful in determining a patient’s prognosis for locally advanced adenocarcinoma of the esophagogastric junction. Researchers also found that those who did not respond to chemotherapy did not benefit from additional radiation. The study results were presented during the eighth annual Gastrointestinal Cancers Symposium,…

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Added by Peter Hofland, PhD on January 20, 2011 at 6:30pm — No Comments

Positive Phase II Results with Iniparib (BSI-201) in Women with Metastatic Triple Negative Breast Cancer

Final phase II data for the investigational drug iniparib (BSI-201) demonstrates significant clinical benefit in women with metastatic triple negative breast cancer (mTNBC) when iniparib was administered in combination with chemotherapy agents gemcitabine/carboplatin.[1] [2]



Triple-negative breast cancer (TNBC) is an aggressive cancer subtype associated with defects in DNA repair mechanism, including BRCA1 dysfunction. This makes this cancer a rational…

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Added by Peter Hofland, PhD on January 5, 2011 at 7:00pm — No Comments

Intensive Chemotherapy May Dramatically Boost Survival of Older Teenage Leukemia Patients

Research led by St. Jude Children's Research Hospital investigators will likely impact how acute lymphoblastic leukemia is treated in young adults and shows older adolescent age does not dictate worse outcomes against the most common childhood cancer. More effective risk-adjusted chemotherapy and sophisticated patient monitoring helped push cure rates to nearly 88% for older adolescents enrolled in a St. Jude Children's…

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Added by Peter Hofland, PhD on December 20, 2010 at 2:30pm — No Comments

Weight of Babies Exposed to Intrauterine Chemotherapy Tended to be Higher

Do not delay treatment of breast cancer just because a woman is pregnant, said lead researcher Sibylle Loibl, Dr. med, of the German Breast Group. This suggestion is based on study results detailing the effects of different treatment options on the infant. Loibl presented this data at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 8-12, 2010.



“At the time we started the study in 2003, there was hardly any information on breast cancer… Continue

Added by Peter Hofland, PhD on December 11, 2010 at 12:30pm — No Comments

Bevacizumab Plus Chemotherapy in Early Breast Cancer is Feasible Treatment Option for Early HER2-Negative Breast Cancer

Results of the GeparQuinto study, randomized Phase III efficacy data on the use of bevacizumab plus chemotherapy to treat women with early breast cancer will be presented at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium.



Gunter von Minckwitz, M.D., Ph.D., managing director of the German Breast Group, and colleagues are conducting final analyses on efficacy data from this study, which will detail the early treatment of more than 1,900…

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Added by Peter Hofland, PhD on December 10, 2010 at 12:30pm — No Comments

Study Shows BSGI/MBI is More Accurate in Establishing Tumor Size After Neoadjuvant Chemotherapy in Patients With Breast Cancer Than Other Imaging Modalities

Dr.Christine Teal, Chief of Breast Surgery, and others of The George Washington University Medical Center in Washington, D.C., determined that Breast-Specific Gamma Imaging/Molecular Breast Imaging (BSGI/MBI) is accurate in establishing tumor size within 5 mm after receiving neoadjuvant chemotherapy (pre-chemotherapy) in patients with breast cancer.



The data from the retrospective study demonstrated that BSGI was superior to that of other imaging techniques… Continue

Added by Peter Hofland, PhD on November 4, 2010 at 5:00am — No Comments

New Research Shows That Girls With Ovarian Germ-cell Tumors Can Safely Skip Chemotherapy Unless Disease Recurs

Researchers from Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) have found that as many as 50% of young girls treated for germ-cell ovarian tumors might safely be spared chemotherapy using a "watch and wait" strategy to determine if the follow-up treatment is needed.



In contrast… Continue

Added by Peter Hofland, PhD on October 22, 2010 at 1:30pm — No Comments

Adding The Anti-EGFR Antibody Cetuximab To Chemotherapy May Doubles Response Rates In Hard-to-Treat Triple-negative Breast Cancer

European researchers have proven for the first time that targeting the epidermal growth factor receptor can provide substantial clinical benefit for women with hard-to-treat triple-negative breast cancer.



At the 35th Congress of the European Society for Medical Oncology (ESMO) in Milan, Italy, the researchers presented results from a Phase-II randomized trial showing that adding the anti-EGFR antibody cetuximab (… Continue

Added by Peter Hofland, PhD on October 11, 2010 at 6:30am — No Comments

Study Shows: Intensive Chemotherapy May Be Harmful to Most Older Patients With Acute Myeloid Leukemia

The prognosis for nearly three-quarters of elderly patients on intensive chemotherapy for acute myeloid leukemia (AML) is poor, with a median survival of less than six months, according to a study published online today in Blood, the journal of the American Society of Hematology. AML is the most common form of acute leukemia among adults and is a rapidly growing cancer… Continue

Added by Peter Hofland, PhD on July 28, 2010 at 10:00am — No Comments

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