International Oncology Network - Cancer & Hematology News

All Blog Posts Tagged 'FAK' (3)

Novel FAK Inhibitors Decrease Pancreatic Cancer Tumor Blood Flow and Reduce Blood Vessel Density

Pre-clinical research results presented at the European Society for Medical Oncology (ESMO) 13th World Congress on Gastrointestinal Cancer in Barcelona, Spain shows that novel Focal Adhesion Kinase (FAK) inhibitors targeting the binding site of vascular endothelial growth factor receptor 3 (VEGFR-3) decrease pancreatic cancer tumor blood flow and reduce blood vessel density in vivo. The research was conducted by scientists of… Continue

Added by Peter Hofland, PhD on June 23, 2011 at 5:30pm — No Comments

High-density Lipoprotein with Gene-silencing siRNA Targets Tumors and Spare Normal Tissue

High-density lipoprotein's - "good cholesterol" hauls excess cholesterol to the liver for disposal, but new research suggests "good cholesterol" can also act as a special delivery vehicle of destruction for cancer. Synthetic HDL nanoparticles loaded with small interfering RNA to silence cancer-promoting genes selectively shrunk or destroyed ovarian cancer tumors in mice, a research team led by scientists from The University of Texas MD Anderson Cancer Center and the University of… Continue

Added by Peter Hofland, PhD on April 1, 2011 at 2:30pm — No Comments

Orphan Drug Designation for FAK Inhibitor in Treatment of Pancreatic Cancer

Focal Adhesion Kinase (FAK), a member of a family of nonreceptor protein-tyrosine kinases, is substantially over-expressed in many cancers, including breast, thyroid, prostate, colon, cervical, ovarian, liver and pancreatic cancer [1, 2]. FAK operates by placing itself at the contact points between tumor cells and the extra cellular matrix that surrounds them.

Researchers have found that FAK is an important facilitator for signals that cause tumor cells to…

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Added by Peter Hofland, PhD on January 18, 2011 at 3:30pm — No Comments