The U.S. Supreme Court heard arguments Monday in a case seeking to invalidate patents on two genes associated with hereditary breast and ovarian cancer. The American College of Medical Genetics and Genomics (ACMG) was one of the first plaintiffs to sign onto this historic legal case.

The American College of Medical Genetics and Genomics was also the first professional medical association to establish a position…

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According to researchers, initial phase I, first in-human, trial results for TKM-080301, also known as TKM-PLK1, indicate that a potential new class of drugs called RNA interference (RNAi) drugs, can be safely administered in humans. The early results for the drug, which is being developed by Tekmira Pharmaceuticals Corporation, were presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10, 2013.

Commenting on the early trial results, Ramesh K.…

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MicroRNAs are short non-coding RNAs that posttranscriptionally modulate the expression of multiple target genes. They are implicated in a wide range of cellular and developmental processes. The microRNA (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, is highly expressed in both activated B and T cells and in monocytes/macrophages. Research has shown that miR-155 levels change dynamically during both hematopoietic lineage differentiation and the…

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Researchers at the Translational Genomics Research Institute (TGen) and its collaborators have identified a rare, inherited mutation linked to a significantly higher risk of prostate cancer.



A study led by Johns Hopkins University School of Medicine and the University of Michigan…

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The validation of a test, based on gene expression and predicting the tumours that will metastasize in lymph nodes of head & neck cancers, was presented today at the 3rd International Conference on innovative approaches in Head and Neck Oncology (ICHNO), in Barcelona, Spain.



Robert P. Takes, MD, from the Radboud University Nijmegen Medical Centre, Nijmegen, the… Continue

For several decades, researchers have been linking genetic mutations to diseases ranging from cancer to developmental abnormalities. What hasn't been clear, however, is how the body's genome sustains such destructive glitches in the first place. Now a team of scientists and research collaborators at the Mayo Clinic provide an unprecedented glimpse of a little-understood gene, called MMSET, revealing how it enables…

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Molecular staging or genomic profiling holds promise in predicting the long-term outcome of an individual patient based on the gene expression profile of their cancer at diagnosis. Researchers have shown that a gene signature test – called ColoPrint – that analyzes the expression of 18 genes can identify the risk of recurrence in colorectal cancer patients with localized, stage II disease.



Such a gene signature test could have important implications for…

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Researchers at The Children's Hospital of Philadelphia have identified variations in a gene as important contributors to neuroblastoma, the most common solid cancer of early childhood.



The study team, led by researchers at The Children's Hospital of Philadelphia, found that common variants in the LMO1 gene increase the risk of developing an aggressive form of neuroblastoma, and also mark the gene for… Continue

Scientists at Dana-Farber Cancer Institute say they have for the first time partially reversed age-related degeneration in mice, resulting in new growth of the brain and testes, improved fertility, and the return of a lost cognitive function.



In a report posted online by the journal Nature in advance of print publication, researchers led by… Continue