Peter Hofland, PhD's Blog Posts Tagged 'NCI' (31)

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Colorectal Cancer Screening and African Americans: It's about Prevention, Not Just Detection

If a screening test could not only catch cancer early but also help to prevent it, could you think of any reason not to have the test? Today, all widely used cancer screening tests aim to detect cancer early, when treatment may be more successful. But several screening tests can also help find abnormal cells that have not yet become cancer, allowing them to be removed before they can cause problems. Colorectal cancer screening tests, for example, can help detect pre-cancerous growths…

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Added by Peter Hofland, PhD on March 15, 2013 at 1:30pm — No Comments

Patients With Lung Cancer and KRAS Gene Mutation Respond Well to Antifolate Therapy

Testing patients with non-small cell lung cancer (NSCLC) for both mutations and amplifications of the KRAS gene prior to therapy may help to predict response to treatment with antifolates, according to the updated results of a preclinical study,funded by the Quintiles Translational Research and Development Group and presented at the AACR Annual Meeting 2012, held in Chicago, March 31 - April 4.



Patients, especially those with lung cancer, who have KRAS…

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Added by Peter Hofland, PhD on April 4, 2012 at 12:00pm — No Comments

Epigenetic Therapy Extends Median Survival in Hard-to-treat Lung Cancer

Patients with recurrent metastatic non-small cell lung cancer (NSCLC) have a morbid prognosis, but a new epigenetic therapy may have potential for this population, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research (AACR), the world’s oldest and largest professional organization dedicated to advancing cancer research.



A research team at…

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Added by Peter Hofland, PhD on November 9, 2011 at 4:00pm — No Comments

Cetuximab Approved to Treat Late-stage Head and Neck Cancer

The U.S. Food and Drug Administration today approved cetuximab Erbitux (Bristol-Myers Squibb)for use with chemotherapy to treat patients with late-stage (metastatic) head and neck cancer.



Combined with chemotherapy, cetuximab extended the lives of those receiving the treatment combination compared with those receiving chemotherapy alone. Cetuximab already is FDA-approved for certain types of colon…

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Added by Peter Hofland, PhD on November 7, 2011 at 11:30am — No Comments

Study Shows Definitive Proof of COTI-2 Target and Single Agent Effectiveness

Results a recent clinical trial confirm that COTI-2, a novel small molecule that acts by inhibiting Akt/PKB (Protein kinase B) phosphorylation leading to caspase-9 activation in cancer cells resulting in tumor cell death, is a promising new targeted therapy candidate. The trial clearly demonstrated that COTI-2 can significantly inhibit the growth of cancer cells that over express Akt/Akt2, which is a key component of the PI3K/Akt/mTOR

signaling pathway and is involved in cell… Continue

Added by Peter Hofland, PhD on August 16, 2011 at 9:30am — No Comments

Supercomputer Analysis to Aid in Matching Targeted Drugs to Lung Cancer Patients

The National Cancer Institute (NCI)is collaborating with GNS Healthcare, a subsidiary of Via Science, a healthcare IT company that applies machine learning and simulation technology to optimize patient treatment, to accelerate lung cancer research with a supercomputing platform that can rapidly uncover cause-and-effect mechanisms hidden in huge data sets assembled from… Continue

Added by Peter Hofland, PhD on July 12, 2011 at 5:30am — No Comments

Does Breast Augmentation Increase the Risk of Breast Cancer: What Women Need to Know

With the increase of negative reports in both print, online and broadcast media, many women around the world wonder if there is a connection between breast augmentation and breast cancer. The U.S. Food and Drug Administration (FDA) continues to support the use of breast implants, as extensive studies have proven their safety.



Earlier this year, the FDA reviewed a possible link between breast implants and a rare… Continue

Added by Peter Hofland, PhD on July 5, 2011 at 5:00am — No Comments

Adjunctive Use of Non-Invasive Diagnostic Helps to Clarify False Positive Results from CT Screening

An adjunctive use of a non-invasive test developed by VisionGate can improve the utility of low dose x-ray computed tomography (CT) screening for the early detection of lung cancer in high risk individuals. The LuCED™ test uses Cell-CT™, VisionGate's revolutionary automated 3D cell imaging platform which generates high-resolution 3D biosignatures from intact cells using a sputum sample. The data will be presented at the… Continue

Added by Peter Hofland, PhD on July 4, 2011 at 12:30am — No Comments

First Validated Screening Leads to 20% Reduction of Mortality Due to Lung Cancer.

Scientists have found a 20% percent reduction in deaths from lung cancer among current or former heavy smokers who were screened with low-dose helical computed tomography (CT) versus those screened by chest X-ray. The primary research results from the National Lung Screening Trial (NLST) were published online today in the New England Journal of Medicine.



This article provides a… Continue

Added by Peter Hofland, PhD on June 29, 2011 at 8:30pm — No Comments

Proteins in Blood Serum Distinguish Cancer From Non-cancerous Conditions, Study Shows

Researchers at the University of Michigan Comprehensive Cancer Center have identified a protein that shows distinct changes in structure between pancreatic cancer, non-cancerous diseases and normal blood serum. The protein also changes from early stage pancreatic cancer to advanced disease.



The finding suggests a blood test could serve as a potential screening tool to detect pancreatic cancer – which has… Continue

Added by Peter Hofland, PhD on April 28, 2011 at 6:30pm — No Comments

New Medical Device to Treat Adults with Glioblastoma Multiforme Approved

The U.S. Food and Drug Administration recently approved the NovoTTF-100A System (Novocure), a new device to treat adults with glioblastoma multiforme (GBM) that recurs or progresses after receiving chemotherapy and radiation therapy.



Brain tumors are the growth of abnormal cells in the brain tissue. According to the National Cancer Institute, each year… Continue

Added by Peter Hofland, PhD on April 15, 2011 at 12:30pm — No Comments

Project Shows that Cancer Recurrence does Not Increase in Breast Cancer Survivors Who eat Soy Food

Soy food consumption did not increase the risk of cancer recurrence or death among survivors of breast cancer, according to research presented at the 102nd Annual Meeting of the American Association for Cancer Research (AACR), held April 2-6, 2011 at the Orange County Convention Center in Orlando, Florida.



Researchers investigated the association between soy food intake and breast cancer outcomes among… Continue

Added by Peter Hofland, PhD on April 5, 2011 at 1:00pm — No Comments

Nicotine not Linked to Tumor Incidence in Mouse Models

Nicotine at doses similar to those found in most nicotine replacements therapies did not increase lung cancer tumor incidence, frequency or size, according to research presented at the 102nd Annual Meeting of the American Association for Cancer Research, held April 2-6, 2011 at the Orange County Convention Center in Orlando, Florida.



“If you take our data and combine it with epidemiological data from Europe,… Continue

Added by Peter Hofland, PhD on April 4, 2011 at 1:00pm — No Comments

AIDS Patients Have Almost Seven-fold Increased Risk of Malignancies of the Stomach

Among people with AIDS, the risk of stomach and esophageal malignancies is higher than among the general population, according to research presented at the 102nd Annual Meeting of the American Association for Cancer Research, held April 2-6, 2011 at the Orange County Convention Center in Orlando, Florida.



“People diagnosed with AIDS are living longer due to improved therapies. However, they are at increased risk of developing a number of different cancers,… Continue

Added by Peter Hofland, PhD on April 4, 2011 at 1:00pm — No Comments

Patients with BRCA2 Mutations have Better Survival for Ovarian Cancer

Women with ovarian cancer who have the BRCA2 gene mutation are more likely to survive the malignancy than women with the BRCA1 mutation, or women without either mutation. In results presented at the 102nd Annual Meeting of the American Association for Cancer Research, held April 2-6, 2011 at the Orange County Convention Center in Orlando, Florida, Kelly Bolton, a fellow at the National Cancer Institute, said the findings describe… Continue

Added by Peter Hofland, PhD on April 4, 2011 at 1:00pm — No Comments

First 3-D Mammography Imaging System Approved for use in US May Boost Acuracy in Beast Cancer Detection and Diagnosis

The U.S. Food and Drug Administration (FDA) today approved the Selenia Dimensions System, the first X-ray mammography device that provides three-dimensional (3-D) images of the breast for breast cancer screening and diagnosis.



A mammogram is a safe, low-dose X-ray of the breast that is the best tool for early detection of breast cancer. However, with the limitations of conventional two-dimensional (2-D)… Continue

Added by Peter Hofland, PhD on February 11, 2011 at 11:30am — No Comments

New Strength Sodium Fluoride F18 as Alternative for Technetium-99m Approved for Use in Bone Scans

The U.S. Food and Drug Administration (FDA) has approved a New Drug Application (NDA) from the National Cancer Institute (NCI), part of the National Institutes of Health, for a new strength of a previously approved drug, Sodium Fluoride F18, for use in bone scans.



In contrast to Technetium-99m (Tc-99m), which has been the only approved radioactive tracer for… Continue

Added by Peter Hofland, PhD on February 1, 2011 at 6:30pm — No Comments

Study to Develop Inexpensive Blood Screening Test for Pancreatic Cancer Launched

A clinical research study to develop a rapid and inexpensive blood screening test for the early diagnosis of pancreatic cancer has been launched by Henry Ford Health System (Detroit, Michigan) and the Barbara Ann Karmanos Cancer Institute (Detroit, Michigan). Funding for the study was provided by Sky…

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Added by Peter Hofland, PhD on January 13, 2011 at 7:00am — No Comments

Study Shows Protein Wields Phosphate Group to Inhibit Cancer Metastasis

By sticking a chemical group to it at a specific site, a protein arrests an enzyme that may worsen and spread cancer, an international research team led by scientists at The University of Texas MD Anderson Cancer Center reports in the January 2011 issue of Nature Cell Biology.



In addition to highlighting a novel anti-cancer pathway, the team found that the same… Continue

Added by Peter Hofland, PhD on January 3, 2011 at 4:30pm — No Comments

Phase I/II Trial of PI-3 Kinase Inhibitor PX-866 in Combination with Cetuximab for the Treatment of CRC or SCCHN Starts Recruiting Participants

Enrollment of the first patient in a Phase I/II trial of PX-866 in combination with the chimeric monoclonal antibody cetuximab (Erbitux®, ImClone LLC/Bristol-Myers Squibb Company) started today. PX-866 is a small molecule compound designed to inhibit the activity of phosphatidylinositol-3-kinase (PI-3K), a component of an important cell survival signaling pathway is activated in many types of human cancer. Aberrant activation…

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Added by Peter Hofland, PhD on December 20, 2010 at 8:00am — No Comments

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