Research published in Nature Medicine shows that boosting a protein pathway in the body's blood making system protects mice from otherwise fatal radiation poisoning. Scientists in the multi-institutional study – posted online by the journal on June 24, 2012 – say their findings open the potential for new treatments against radiation toxicity during cancer treatment or environmental… Continue
Added by Peter Hofland, PhD on June 24, 2012 at 10:00am —
Researchers studying the molecular signals that drive a specific type of lymphoma have discovered a key biological pathway leading to this type of cancer. Cancerous cells have been described as being "addicted" to certain oncogenes or cancer-causing genes, and the new research may lay the groundwork for breaking that addiction and effectively treating aggressive types of B cell lymphoma. Continue
B cell lymphomas, which occur both in children and adults, are cancers that…
Added by Peter Hofland, PhD on May 7, 2012 at 12:00am —
Tracking the genetic pathway of a disease offers a powerful, new approach to drug discovery, according to scientists at the University of California, San Diego School of Medicine who used the approach to uncover a potential treatment for prostate cancer, using a drug currently marketed for congestive heart failure. Their findings are published in the current… Continue
Added by Peter Hofland, PhD on March 13, 2012 at 5:30pm —
Despite the widespread use of current antiangiogenic cancer therapies, many tumors escape this blockade, which is designed to shut down growth of new blood vessels that feed tumors and spread cancer cells. Now, a study reported at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics (November 12-16, 2011, Moscone Center West, San Francisco, CA)suggests that targeting a novel antiangiogenic receptor may help patients whose cancer does not respond… Continue
Added by Peter Hofland, PhD on November 13, 2011 at 11:30am —
Amplification of anaplastic lymphoma kinase, which has been reported in other cancers such as non-small cell lung cancers (NSCLC), may be a primary driver of the rapid metastasis that patients with inflammatory breast cancer experience. If validated, the use of anaplastic lymphoma kinase (ALK) inhibitors may be a new treatment approach for patients with this lethal form of breast cancer. Continue
These data were presented at the AACR-NCI-EORTC International…
Added by Peter Hofland, PhD on November 13, 2011 at 9:00am —
Glioblastoma is the most common, most aggressive and untreatable form of malignant primary brain tumors in humans involving the glial cells. The disease accounts for 52% of all functional tissue brain tumor cases and 20% of all intracranial tumors and occurs in only 2–3 cases per 100,000 people in Europe and North America. Median survival times are between 12 to 15 months. Because glioblastoma is resistant to conventional therapies, including the most aggressive chemotherapy and… Continue
Added by Peter Hofland, PhD on September 15, 2011 at 4:30pm —
The epidermal growth factor receptor (EGFR) gene is essential for KRAS-driven pancreatic cancer development, according to study results presented at the Second AACR International Conference on Frontiers in Basic Cancer Research, held in San Francisco, September 14-18, 2011. Continue
The mutation of the KRAS gene has been found to be an important component in the development of many cancers, including pancreatic cancer. However, Barbara M. Gruener, researcher at the…
Added by Peter Hofland, PhD on September 15, 2011 at 11:00am —
Researchers at St. Jude Children's Hospital have identified a signaling molecule that functions like a factory supervisor to ensure that the right mix of specialized T cells is available to fight infections and guard against autoimmune disease.
The research also showed the molecule, phosphatase MKP-1, is an important regulator of immune balance. Working in laboratory cell lines and mice with specially… Continue
Added by Peter Hofland, PhD on July 22, 2011 at 8:30am —
Scientists identify in the journal Nature a new molecular pathway used to suppress blood vessel branching in the developing retina – a finding with potential therapeutic value for fighting diseases of the retina and a variety of cancers.
The researchers report that myeloid cells, blood cells involved in the immune system, use this molecular pathway to guide… Continue
Added by Peter Hofland, PhD on May 29, 2011 at 10:00am —
People with a genetic condition called basal cell nevus syndrome develop hundreds or even thousands of skin cancers, or basal cell carcinomas, each year. Now Jean Tang, MD, PhD, assistant professor of dermatology, is reporting that a drug produced by Genentech called GDC-0449,a synthetic Hedgehog Pathway Inhibitor which blocks signals in the Hedgehog Pathway that is known to play a role in tumor growth,… Continue
Added by Peter Hofland, PhD on April 19, 2011 at 12:00pm —
Prostate tumors that carry a ‘signature’ of four molecular markers have the potential to become dangerously metastatic if not treated aggressively, researchers at Dana-Farber Cancer Institute report in a study published online today by the journal Nature. The discovery lays the groundwork for the first gene-based test for determining whether a man's prostate cancer is likely to… Continue
Added by Peter Hofland, PhD on February 2, 2011 at 4:30pm —
Researchers at The Children's Hospital of Philadelphia have identified variations in a gene as important contributors to neuroblastoma, the most common solid cancer of early childhood.
The study team, led by researchers at The Children's Hospital of Philadelphia, found that common variants in the LMO1
gene increase the risk of developing an aggressive form of neuroblastoma, and also mark the gene for… Continue
Added by Peter Hofland, PhD on December 1, 2010 at 11:00am —
Breast cancer stem cells (CSCs), the aggressive cells thought to be resistant to current anti-cancer therapies and which promote metastasis, are stimulated by estrogen via a pathway that mirrors normal stem cell development. Disrupting the pathway, researchers at Tufts University School of Medicineand the Sackler School of Graduate Biomedical Sciences at Tufts University, were… Continue
Added by Peter Hofland, PhD on November 26, 2010 at 6:30am —
Biologists at Tufts University School of Arts and Sciences have discovered that a change in membrane voltage in newly identified ‘instructor cells’ can cause stem cells' descendants to trigger melanoma-like growth in pigment cells. The Tufts team also found that this metastatic transformation is due to changes in serotonin transport. The discovery could aid in the prevention and treatment of diseases like cancer and… Continue
Added by Peter Hofland, PhD on October 19, 2010 at 11:30am —
Researchers at Whitehead Institute and Children's Hospital Boston have identified a protein, called Musashi 2, that is predictive of prognosis in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) patients.
High levels of Musashi 2 protein is associated with increased cell proliferation, decreased cell maturation, and multiple cancer-related cellular pathways in human leukemias. The protein and the cellular functions it affects could potentially… Continue
Added by Peter Hofland, PhD on July 8, 2010 at 9:30pm —
Blocking two cell signaling pathways leads to dramatic shrinkage of K-Ras-mutated tumors in animal model. This is the conclusion of a team of cancer researchers from several Boston academic medical centers. The team believes that their findings offer a potential treatment for a group of tumors that have resisted previous approaches of treatment with selected targeted therapies.
In their report published in the december issue of Nature Medicine, investigators from… Continue
Added by Peter Hofland, PhD on December 7, 2008 at 5:30pm —