Research published in Nature Medicine shows that boosting a protein pathway in the body's blood making system protects mice from otherwise fatal radiation poisoning. Scientists in the multi-institutional study – posted online by the journal on June 24, 2012 – say their findings open the potential for new treatments against radiation toxicity during cancer treatment or environmental…

Researchers studying the molecular signals that drive a specific type of lymphoma have discovered a key biological pathway leading to this type of cancer. Cancerous cells have been described as being "addicted" to certain oncogenes or cancer-causing genes, and the new research may lay the groundwork for breaking that addiction and effectively treating aggressive types of B cell lymphoma.



B cell lymphomas, which occur both in children and adults, are cancers that…

Tracking the genetic pathway of a disease offers a powerful, new approach to drug discovery, according to scientists at the University of California, San Diego School of Medicine who used the approach to uncover a potential treatment for prostate cancer, using a drug currently marketed for congestive heart failure. Their findings are published in the current…

Despite the widespread use of current antiangiogenic cancer therapies, many tumors escape this blockade, which is designed to shut down growth of new blood vessels that feed tumors and spread cancer cells. Now, a study reported at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics (November 12-16, 2011, Moscone Center West, San Francisco, CA)suggests that targeting a novel antiangiogenic receptor may help patients whose cancer does not respond…

Amplification of anaplastic lymphoma kinase, which has been reported in other cancers such as non-small cell lung cancers (NSCLC), may be a primary driver of the rapid metastasis that patients with inflammatory breast cancer experience. If validated, the use of anaplastic lymphoma kinase (ALK) inhibitors may be a new treatment approach for patients with this lethal form of breast cancer.



These data were presented at the AACR-NCI-EORTC International…

The epidermal growth factor receptor (EGFR) gene is essential for KRAS-driven pancreatic cancer development, according to study results presented at the Second AACR International Conference on Frontiers in Basic Cancer Research, held in San Francisco, September 14-18, 2011.



The mutation of the KRAS gene has been found to be an important component in the development of many cancers, including pancreatic cancer. However, Barbara M. Gruener, researcher at the…