Peter Hofland, PhD's Blog – May 2010 Archive (7)

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ASCO 2010: Lenalidomide Maintenance Therapy Slows Myeloma Progression

Today, high-dose therapy with autologous stem cell transplantation (ASCT) is a standard treatment for myeloma patients. But a residual disease (RD) responsible for relapse is always present. As a result, effective maintenance treatment is required. However, such treatment is still to be defined.



Researchers have found that thalidomide reduced RD. Neuropathy is, however, one of the major limiting factors of thalidomide. Lenalidomide, a thalidomide analog… Continue

Added by Peter Hofland, PhD on May 20, 2010 at 11:30pm — No Comments

ASCO 2010: Maintenance Therapy with Rituximab Halves Risk of Lymphoma Recurrence

The Phase III international PRIMA trial has found that two years of rituximab (Rituxan) "maintenance" therapy reduced the risk of follicular lymphoma recurrence by 50% in patients who responded to initial chemotherapy. Maintenance therapy is longer-term treatment given after patients achieve remission with standard therapy, with the goal of prolonging remission.



"These findings provide hope for the way we manage this disease. Rituximab maintenance therapy is… Continue

Added by Peter Hofland, PhD on May 20, 2010 at 11:30pm — No Comments

ASCO 2010: Older Women with Early-Stage Breast Cancer Can Safely Forego Radiation Therapy

Researchers have shown that in women 70 years of age or older with early breast cancer undergoing lumpectomy, tamoxifen alone (Tam) is an effective alternative to tamoxifen plus radiation (TamRT). The initial results were based on a median follow-up (FU) of 7.9 years.



Results of the follow-up study which will be presented at ASCO provides longer-term results outcomes at a median FU of 10.5 years. This follow-up study adds further evidence that women age 70 or… Continue

Added by Peter Hofland, PhD on May 20, 2010 at 11:30pm — No Comments

ASCO 2010: Promising New Ovarian Cancer Screening Strategy Developed for Post-Menopausal Women at Average Risk

There are virtually no effective screening tools for the early detection of ovarian cancer in women at average population risk of getting the disease. But researchers have now tested a promising new screening approach for post-menopausal women at average risk of ovarian cancer. The strategy uses a mathematical model that combines trends in CA-125 blood test results and a patient's age, followed by transvaginal ultrasound and referral to a gynecologic oncologist, if necessary. The… Continue

Added by Peter Hofland, PhD on May 20, 2010 at 11:30pm — No Comments

ASCO 2010: Heart Problems in Childhood Cancer Survivors Tied to Specific Gene and Drug Dose

A Children’s Oncology Group study has shown that survivors of childhood cancer who carry particular variants of the CBR gene and who received low doses of anthracycline chemotherapy were much more likely to develop heart disease than those without this form of the gene who received low doses.



This finding may guide a more personalized approach to preventing toxicities associated with anthracycline chemotherapy among a…

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Added by Peter Hofland, PhD on May 20, 2010 at 11:30pm — No Comments

ASCO 2010: Important Advances in Targeted Therapies, Screening, and Quality of Life

“Advancing Quality Through Innovation,” the theme of the 46th Annual Meeting the American Society of Clinical Oncology (ASCO), being held from June 4-June 8, 2010, at McCormick Place in Chicago, demonstrates the progress made in understanding cancer and how new therapies many benefit patients today and in the future. The meeting is expected to draw approximately 30,000 cancer specialists.



“Our growing understanding of cancer’s complex behavior is being… Continue

Added by Peter Hofland, PhD on May 20, 2010 at 11:30pm — No Comments

Young Leukemia Patients Benefit from Smarter Use of Existing Treatment

More individualized therapy and better supportive care helped push the survival for children with Acute Myeloid Leukemia (AML) to 71% three years after diagnosis, according to new research led by investigators at St. Jude Children's Research Hospital, an internationally recognized…

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Added by Peter Hofland, PhD on May 10, 2010 at 6:30am — No Comments

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