Results from a large-scale patient population study, supported by the National Cancer Institute of the National Institutes of Health, which was recently published in the Annals of the American Thoracic Society, seems to suggest that palliative care is associated with a reduced risk of suicide in veterans diagnosed with advanced stage lung cancer.
The findings were based on a study of more than 20,000 lung cancer patients enrolled in a cancer patient registry from the VA Central Cancer Registry.
Palliative care is specialized medical care focusing on providing relief from symptoms, pain and stress. In most cases, the goal is to improve health related Quality of Life (hrQoL) for both the patient and the patient’s family. It is considered appropriate at any age and at any stage in an illness and can be provided along with treatment meant to cure.
Donald Sullivan, M.D., M.A, M.C.R., an assistant professor of medicine (pulmonary and critical care medicine) in the OHSU School of Medicine and core investigator at the Center to Improve Veteran Involvement in Care at the Veterans Affairs Portland Health Care System, was the paper’s lead author. Sullivan says the goal of the study was to see whether palliative care, which aims to relieve physical pain and discomfort and to address psychological issues like anxiety that diminish quality of life for those with life-threatening illnesses, reduced suicide rates among veterans with stage IIIB and IV lung cancer.
Of the 20,900 patients with advanced lung cancer enrolled in the registry, 30 patients committed suicide, a rate more than five times greater than the average among all veterans who use VA health care of a similar age and gender. However, the data showed that patients with lung cancer who had at least one palliative care visit after their diagnosis were 81% less likely to die by suicide.
Significant public health problem
Sullivan says the psychological impact of a cancer diagnosis, particularly a lung cancer diagnosis, is underappreciated and largely overlooked in the medical community.
“Suicide is a significant national public health problem, especially among lung cancer patients and among veterans,” said Sullivan, who also is a member of the OHSU Knight Cancer Institute.
“As a result, manifestations of this impact like social isolation, depression, anxiety, can go undiagnosed and untreated,” he added.
Sullivan believes this is the first study to explore the relationship between palliative care and suicide risk in cancer patients.
Barriers to palliative care
According to Sullivan, several medical societies recommend palliative care for all patients with advanced stage lung cancer, but there is often a gap between recommendations and practice.
“There are many barriers to palliative care, and unfortunately, some are related to clinician referrals,” he says. “Not all doctors are aware of the benefits of palliative care.”
Sullivan believes that palliative care should be offered to all patients shortly after receiving a diagnosis of advanced stage lung cancer. The best scenario, he says, is an integrated approach in which patients with serious illness receive palliative care at the same time they receive other treatment therapies like chemotherapy.
Reaching out for help
Sullivan says it’s important for clinicians treating patients with lung cancer to be vigilant in recognizing the presence of one or more additional diseases or disorders, such as cobmorbid psychological illness, in their patients and become familiar with local resources.
“For patients and families, it’s important to understand these risks exist and not to be afraid to reach out to your providers for help,” he says.
This study was an exploratory analysis, Sullivan explains, and at further research would require a very large patient population given the overall incidence of suicide. In short, a randomized trial of this magnitude would be a difficult task, he says, and one that would require many years to complete.
This is time that some patients don’t have.
“We really can’t afford to wait for more data,” he says. “I would like to see more efforts to screen and treat comorbid psychological illness among patients with lung cancer for which there is good evidence. I also believe more efforts are needed to integrate palliative care earlier in the lung cancer treatment paradigm.”
 Sullivan DR, Forsberg CW, Golden SE, Ganzini L, Dobscha SK, Christopher, Slatore CG. Incidence of Suicide and Association with Palliative Care among Patients with Advanced Lung Cancer. Ann Am Thorac Soc. 2018 Jul 26. doi: 10.1513/AnnalsATS.201805-299RL. [Epub ahead of print]
Last Editorial Review: August 10, 2018
Featured Image: Doctor looking at Lung Cancer. Courtesy: © 2010 – 2018 Fotolia. Used with permission. Photo 1.0: Donald Sullivan, M.D., M.A., M.C.R., assistant professor of medicine (pulmonary and critical care medicine) in the OHSU School of Medicine. and core investigator at the Center to Improve Veteran Involvement in Care at the Veterans Affairs Portland Health Care System. Courtesy: © 2010 – 2018 OHSU/Kristyna Wentz-Graff. Used with permission.
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